Modulation of age-associated oxidative DNA damage in rat brain cerebral cortex, striatum and hippocampus by L-carnitine

被引：33

作者：

Haripriya, D ^{[1
]}

Sangeetha, P ^{[1
]}

Kanchana, A ^{[1
]}

Balu, M ^{[1
]}

Panneerselvam, C ^{[1
]}

机构：

[1] Univ Madras, Dept Biochem Med, Dr AL Mudaliar Post Grad Inst Basic Med Sci, Madras 600113, Tamil Nadu, India

来源：

EXPERIMENTAL GERONTOLOGY | 2005年 / 40卷 / 03期

关键词：

aging; 8-OHdG; DNA protein cross-links; L-carnitine; cortex; striatum; hippocampus;

D O I：

10.1016/j.exger.2004.10.006

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The free radical theory of cell aging may have significant relevance in the pathogenesis of a number of age-related neurological disorders. A large body of experimental evidence supports the existence of a relationship between genomic instability, DNA damage and aging. The age-associated accumulation of oxidative DNA damage is well documented in central nervous system. The decline of mitochondrial respiratory function and loss of normal cellular homeostasis as consequences of excessive accumulation of endogenous oxidative damages to DNA have long been indicated in the aging process. In the present study, age-associated alterations in the content of DNA and accumulation of oxidative DNA damage products such as 8-OHdG and DNA protein cross-links are mainly focused. In parallel, we have also investigated the salubrious effect Of L-carnitine against oxidative DNA damage as it possesses energy and antioxidant improving properties. Our results thus reveal that L-carnitine has inhibiting effect on the accumulation of age-related oxidative DNA damage in various brain regions, viz. cerebral cortex, striatum and hippocampus. (c) 2004 Elsevier Inc. All rights reserved.

引用

页码：129 / 135

页数：7

共 42 条

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