Cognitive and imaging markers in non-demented subjects attending a memory clinic: study design and baseline findings of the MEMENTO cohort

被引：48

作者：

Dufouil, Carole ^{[1
,2
]}

Dubois, Bruno ^{[3
,4
]}

Vellas, Bruno ^{[5
]}

Pasquier, Florence ^{[6
,7
]}

Blanc, Frederic ^{[8
]}

Hugon, Jacques ^{[9
]}

Hanon, Olivier ^{[10
,11
]}

Dartigues, Jean-Francois ^{[1
,12
]}

Harston, Sandrine ^{[13
]}

Gabelle, Audrey ^{[14
]}

Ceccaldi, Mathieu ^{[15
]}

Beauchet, Olivier ^{[16
]}

Krolak-Salmon, Pierre ^{[17
]}

David, Renaud ^{[18
]}

Rouaud, Olivier ^{[19
]}

Godefroy, Olivier ^{[20
]}

Belin, Catherine ^{[21
]}

Rouch, Isabelle ^{[22
]}

Auguste, Nicolas ^{[23
]}

Wallon, David ^{[24
]}

Benetos, Athanase ^{[25
]}

Pariente, JRMie ^{[26
]}

Paccalin, Marc ^{[27
]}

Moreaud, Olivier ^{[28
]}

Hommet, Caroline ^{[29
]}

Sellal, Francois ^{[30
,31
]}

Boutoleau-Bretonniere, Claire ^{[32
]}

Jalenques, Isabelle ^{[33
]}

Gentric, Armelle ^{[34
]}

Vandel, Pierre ^{[35
]}

Azouani, Chabha ^{[36
,37
]}

Fillon, Ludovic ^{[36
,37
]}

Fischer, Clara ^{[36
,37
]}

Savarieau, Helen ^{[1
,2
]}

Operto, Gregory ^{[36
,37
]}

Bertin, Hugo ^{[36
,38
,39
]}

Chupin, Marie ^{[36
,37
]}

Bouteloup, Vincent ^{[1
,2
]}

Habert, Marie-Odile ^{[38
,39
]}

Mangin, Jean-Francois ^{[36
,40
]}

Chene, Genevieve ^{[1
,2
]}

机构：

[1] Univ Bordeaux, Ctr Inserm U1219, ISPED, Bordeaux Sch Publ Hlth, 146 Rue Leo Saignat, F-33076 Bordeaux, France

[2] CHU Bordeaux, Pole Sante Publ, F-33000 Bordeaux, France

[3] Sorbonne Univ, Pierre & Marie Curie Univ, Pitie Salpetriere Univ Hosp, AP HP,Inst Memory & Alzheimers Dis IM2A, F-75006 Paris, France

[4] Sorbonne Univ, Pierre & Marie Curie Univ, Pitie Salpetriere Univ Hosp, AP HP,Brain & Spine Inst ICM,Dept Neurol,UMRS 112, F-75006 Paris, France

[5] Hop Grave Casselardit, CHU Toulouse, Memory Resource & Res Ctr Toulouse, F-31000 Toulouse, France

[6] Hop Roger Salengro, CHRU Lille, Memory Resource & Res Ctr Lille, F-59000 Lille, France

[7] Univ Lille, INSERM, U1171, F-59000 Lille, France

[8] Hop Univ Strasbourg, Memory Resource & Res Ctr Strasbourg Colmar, Dept Geriatr, FMTS,Lab ICube UMR 7357, F-67000 Strasbourg, France

[9] Grp Hosp St Louis Lariboisiere Fernand Widal, AP HP, Memory Resource & Res Ctr Paris Nord, F-75010 Paris, France

[10] Hop Broca, AP HP, Memory Resource & Res Ctr Paris Broca, F-75013 Paris, France

[11] Univ Paris 05, Sorbonne Paris Cite, F-EA4468 Paris, France

[12] Hop Pellegrin, CHU Bordeaux, Memory Resource & Res Ctr Bordeaux, F-33000 Bordeaux, France

[13] Hop Xavier Arnozan, CHU Bordeaux, Memory Resource & Res Ctr Bordeaux, F-33000 Bordeaux, France

[14] Hop Gui De Chauliac, CHU Montpellier, Memory Resource & Res Ctr Montpellier, F-34000 Montpellier, France

[15] Hop La Timone, CHU Marseille, Memory Resource & Res Ctr Marseille, F-13000 Marseille, France

[16] CHU Angers, Memory Resource & Res Ctr Angers, F-49000 Angers, France

[17] Hop Charpennes, Hosp Civils Lyon, Memory Resource & Res Ctr Lyon, F-69000 Lyon, France

[18] CHU Nice, EA CoBTeK Cognit Behav Technol 7276, Inst Claude Pompidou, Memory Resource & Res Ctr Nice, F-06100 Nice, France

[19] Hop Champmaillot, Hop Bocage, CHU Dijon Bourgogne, Memory Resource & Res Ctr Dijon, F-21000 Dijon, France

[20] Hop Nord Amiens, CHU Amiens Picardie, Memory Resource & Res Amiens, F-80000 Amiens, France

[21] Hop Univ Paris Seine St Denis, AP HP, Hop Avicenne, Memory Clin, F-93009 Bobigny, France

[22] Hop Nord St Etienne, CHU St Etienne, Memory Resource & Res Ctr St Etienne, F-42000 St Etienne, France

[23] Hop Charite, CHU St Etienne, Memory Resource & Res Ctr St Etienne, F-42000 St Etienne, France

[24] Rouen Univ Hosp, Dept Neurol, Memory Resource & Res Ctr Rouen, F-76031 Rouen, France

[25] CHU Nancy, Memory Resource & Res Ctr Nancy, F-54000 Nancy, France

[26] Hop Purpan, CHU Toulouse, Memory Resource & Res Ctr Toulouse, F-31000 Toulouse, France

[27] Hop La Miletrie, CHU Poitiers, Memory Resource & Res Ctr Poitiers, F-86000 Poitiers, France

[28] Hop Tronche, CHU Grenoble Alpes, Memory Resource & Res Ctr Grenoble, F-38000 Grenoble, France

[29] Hop Bretonneau, CHRU Tours, Memory Resource & Res Ctr Ctr Reg, F-37000 Tours, France

[30] Hop Civils Colmar, Memory Resource & Res Ctr Strasbourg Colmar, F-68000 Colmar, France

[31] Strasbourg Univ, Inserm U118, F-67000 Strasbourg, France

[32] CHU Nantes, Memory Resource & Res Ctr Nantes, F-44000 Nantes, France

[33] CHU Clermont Ferrand, Memory Resource & Res Ctr Clermont Ferrand, F-63000 Clermont Ferrand, France

[34] CHRU Brest, Memory Resource & Res Ctr Brest, F-29000 Brest, France

[35] Hop Jean Minjoz, Hop St Jacques, CHU Besancon, Memory Resource & Res Ctr Besancon, F-25000 Besancon, France

[36] Ctr Acquisit & Traitement Images, NeuroSpin, I2BM, Commissariat Energie Atom, F-91400 Orsay, France

[37] Sorbonne Univ, Univ Paris 06, UPMC, Inserm,CNRS,ICM,Hop Pitie Salpetriere,Blvd Hop, F-75013 Paris, France

[38] Pitie Salpetriere Univ Hosp, AP HP, Nucl Med Dept, F-75006 Paris, France

[39] Univ Paris 06, Sorbonne Univ, Lab Imagerie Biomed, UPMC,Inserm,CNRS UMR 7371,U1146, F-75006 Paris, France

[40] Univ Paris Saclay, NeuroSpin, I2BM, Commissariat Energie Atom, F-91400 Orsay, France

来源：

ALZHEIMERS RESEARCH & THERAPY | 2017年 / 9卷

关键词：

Alzheimer's disease; Cognitive aging; Cohort studies; Natural history studies (prognosis); Neuroimaging; EMISSION-TOMOGRAPHY IMAGES; FRONTAL ASSESSMENT BATTERY; ALZHEIMERS-DISEASE; DEMENTIA; IMPAIRMENT; SEGMENTATION; PREVALENCE; HIPPOCAMPUS; RECOGNITION; PREDICTION;

D O I：

10.1186/s13195-017-0288-0

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: The natural history and disease mechanisms of Alzheimer's disease and related disorders (ADRD) are still poorly understood. Very few resources are available to scrutinise patients as early as needed and to use integrative approaches combining standardised, repeated clinical investigations and cutting-edge biomarker measurements. Methods: In the nationwide French MEMENTO cohort study, participants were recruited in memory clinics and screened for either isolated subjective cognitive complaints (SCCs) or mild cognitive impairment (MCI; defined as test performance 1.5 SD below age, sex and education-level norms) while not demented (Clinical Dementia Rating [CDR] < 1). Baseline data collection included neurological and physical examinations as well as extensive neuropsychological testing. To be included in the MEMENTO cohort, participants had to agree to undergo both brain magnetic resonance imaging (MRI) and blood sampling. Cerebral F-18-fluorodeoxyglucose positon emission tomography and lumbar puncture were optional. Automated analyses of cerebral MRI included assessments of volumes of whole-brain, hippocampal and white matter lesions. Results: The 2323 participants, recruited from April 2011 to June 2014, were aged 71 years, on average (SD 8.7), and 62% were women. CDR was 0 in 40% of participants, and 30% carried at least one apolipoprotein E epsilon 4 allele. We observed that more than half (52%) of participants had amnestic mild cognitive impairment (17% single-domain aMCI), 32% had non-amnestic mild cognitive impairment (16.9% single-domain naMCI) and 16% had isolated SCCs. Multivariable analyses of neuroimaging markers associations with cognitive categories showed that participants with aMCI had worse levels of imaging biomarkers than the others, whereas participants with naMCI had markers at intermediate levels between SCC and aMCI. The burden of white matter lesions tended to be larger in participants with aMCI. Independently of CDR, all neuroimaging and neuropsychological markers worsened with age, whereas differences were not consistent according to sex. Conclusions: MEMENTO is a large cohort with extensive clinical, neuropsychological and neuroimaging data and represents a platform for studying the natural history of ADRD in a large group of participants with different subtypes of MCI (amnestic or not amnestic) or isolated SCCs.

引用

页数：13