Emergence of EGFR G724S mutation in EGFR-mutant lung adenocarcinoma post progression on osimertinib

被引：72

作者：

Oztan, A. ^{[1
]}

Fischer, S. ^{[2
]}

Schrock, A. B. ^{[1
]}

Erlich, R. L. ^{[1
]}

Lovly, C. M. ^{[3
]}

Stephens, P. J. ^{[1
]}

Ross, J. S. ^{[1
]}

Miller, V. ^{[1
]}

Ali, S. M. ^{[1
]}

Ou, S. -H. I. ^{[4
]}

Raez, L. E. ^{[5
]}

机构：

[1] Fdn Med Inc, 150 Second St, Cambridge, MA 02141 USA

[2] Providence Med Inst, 2021 Santa Monica Blvd, Santa Monica, CA 90404 USA

[3] Vanderbilt Ingram Canc Ctr, Nashville, TN 37232 USA

[4] Univ Calif Irvine, Sch Med, Dept Med, Chao Family Comprehens Canc Ctr,Div Hematol Oncol, Orange, CA 92868 USA

[5] Mem Healthcare Syst, Mem Canc Inst, 801 N Flamingo Rd, Pembroke Pines, FL 33028 USA

来源：

LUNG CANCER | 2017年 / 111卷

关键词：

EGFR; G724S; T790M; Acquired resistance; Osimertinib; Lung cancer; ACQUIRED-RESISTANCE; GEFITINIB; AZD9291; CHEMOTHERAPY; INHIBITORS;

D O I：

10.1016/j.lungcan.2017.07.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mutations in the epidermal growth factor receptor (EGFR) are drivers for a subset of lung cancers. Osimertinib is a third-generation tyrosine kinase inhibitor (TIU) recently approved for the treatment of T790M-positive non-small cell lung cancer (NSCLC); however, acquired resistance to osimertinib is evident and resistance mechanisms remain incompletely defined. The EGFR G724S mutation was detected using hybrid-capture based comprehensive genomic profiling (CGP) and a hybrid-capture based circulating tumor DNA (ctDNA) assays in two cases of EGFR-driven lung adenocarcinoma in patients who had progressed on osimertinib treatment. This study demonstrates the importance of both tissue and blood based hybrid-capture based genomic profiling at disease progression to identifying novel resistance mechanisms in the clinic.

引用

页码：84 / 87

页数：4

共 17 条

[1] L718Q Mutation as New Mechanism of Acquired Resistance to AZD9291 in EGFR-Mutated NSCLC [J].

Bersanelli, Melissa ;

Minari, Roberta ;

Bordi, Paola ;

Gnetti, Letizia ;

Bozzetti, Cecilia ;

Squadrilli, Anna ;

Lagrasta, Costanza Anna Maria ;

Bottarelli, Lorena ;

Osipova, Ganna ;

Capelletto, Enrica ;

Mor, Marco ;

Tiseo, Marcello .

JOURNAL OF THORACIC ONCOLOGY, 2016, 11 (10) :E121-+

[2] Colon cancer-derived oncogenic EGFR G724S mutant identified by whole genome sequence analysis is dependent on asymmetric dimerization and sensitive to cetuximab [J].

Cho, Jeonghee ;

Bass, Adam J. ;

Lawrence, Michael S. ;

Cibulskis, Kristian ;

Cho, Ahye ;

Lee, Shi-Nai ;

Yamauchi, Mai ;

Wagle, Nikhil ;

Pochanard, Panisa ;

Kim, Nayoung ;

Park, Angela K. J. ;

Won, Jonghwa ;

Hur, Hyung-Suk ;

Greulich, Heidi ;

Ogino, Shuji ;

Sougnez, Carrie ;

Voet, Douglas ;

Tabernero, Josep ;

Jimenez, Jose ;

Baselga, Jose ;

Gabriel, Stacey B. ;

Lander, Eric S. ;

Getz, Gad ;

Eck, Michael J. ;

Park, Woong-Yang ;

Meyerson, Matthew .

MOLECULAR CANCER, 2014, 13

[3] First-line gefitinib in Caucasian EGFR mutation-positive NSCLC patients: a phase-IV, open-label, single-arm study [J].

Douillard, J-Y ;

Ostoros, G. ;

Cobo, M. ;

Ciuleanu, T. ;

McCormack, R. ;

Webster, A. ;

Milenkova, T. .

BRITISH JOURNAL OF CANCER, 2014, 110 (01) :55-62

[4] Mechanisms of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer [J].

Engelman, Jeffrey A. ;

Jaenne, Pasi A. .

CLINICAL CANCER RESEARCH, 2008, 14 (10) :2895-2899

[5] Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing [J].

Frampton, Garrett M. ;

Fichtenholtz, Alex ;

Otto, Geoff A. ;

Wang, Kai ;

Downing, Sean R. ;

He, Jie ;

Schnall-Levin, Michael ;

White, Jared ;

Sanford, Eric M. ;

An, Peter ;

Sun, James ;

Juhn, Frank ;

Brennan, Kristina ;

Iwanik, Kiel ;

Maillet, Ashley ;

Buell, Jamie ;

White, Emily ;

Zhao, Mandy ;

Balasubramanian, Sohail ;

Terzic, Selmira ;

Richards, Tina ;

Banning, Vera ;

Garcia, Lazaro ;

Mahoney, Kristen ;

Zwirko, Zac ;

Donahue, Amy ;

Beltran, Himisha ;

Mosquera, Juan Miguel ;

Rubin, Mark A. ;

Dogan, Snjezana ;

Hedvat, Cyrus V. ;

Berger, Michael F. ;

Pusztai, Lajos ;

Lechner, Matthias ;

Boshoff, Chris ;

Jarosz, Mirna ;

Vietz, Christine ;

Parker, Alex ;

Miller, Vincent A. ;

Ross, Jeffrey S. ;

Curran, John ;

Cronin, Maureen T. ;

Stephens, Philip J. ;

Lipson, Doron ;

Yelensky, Roman .

NATURE BIOTECHNOLOGY, 2013, 31 (11) :1023-+

[6] Emergence of Preexisting MET Y1230C Mutation as a Resistance Mechanism to Crizotinib in NSCLC with MET Exon 14 Skipping [J].

Ignatius, Sai-Hong ;

Young, Lauren ;

Schrock, Alexa B. ;

Johnson, Adrienne ;

Klempner, Samuel J. ;

Zhu, Viola W. ;

Miller, Vincent A. ;

Ali, Siraj M. .

JOURNAL OF THORACIC ONCOLOGY, 2017, 12 (01) :137-140

[7] AZD9291 in EGFR Inhibitor-Resistant Non-Small-Cell Lung Cancer [J].

Jaenne, Pasi A. ;

Yang, James Chih-Hsin ;

Kim, Dong-Wan ;

Planchard, David ;

Ohe, Yuichiro ;

Ramalingam, Suresh S. ;

Ahn, Myung-Ju ;

Kim, Sang-We ;

Su, Wu-Chou ;

Horn, Leora ;

Haggstrom, Daniel ;

Felip, Enriqueta ;

Kim, Joo-Hang ;

Frewer, Paul ;

Cantarini, Mireille ;

Brown, Kathryn H. ;

Dickinson, Paul A. ;

Ghiorghiu, Serban ;

Ranson, Malcolm .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (18) :1689-1699

[8] ATLAS: Randomized, Double-Blind, Placebo-Controlled, Phase IIIB Trial Comparing Bevacizumab Therapy With or Without Erlotinib, After Completion of Chemotherapy, With Bevacizumab for First-Line Treatment of Advanced Non-Small-Cell Lung Cancer [J].

Johnson, Bruce E. ;

Kabbinavar, Fairooz ;

Fehrenbacher, Louis ;

Hainsworth, John ;

Kasubhai, Saifuddin ;

Kressel, Bruce ;

Lin, Chin-Yu ;

Marsland, Thomas ;

Patel, Taral ;

Polikoff, Jonathan ;

Rubin, Mark ;

White, Leonard ;

Yang, James Chih-Hsin ;

Bowden, Chris ;

Miller, Vincent .

JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (31) :3926-+

[9] Analytical and Clinical Validation of a Digital Sequencing Panel for Quantitative, Highly Accurate Evaluation of Cell-Free Circulating Tumor DNA [J].

Lanman, Richard B. ;

Mortimer, Stefanie A. ;

Zill, Oliver A. ;

Sebisanovic, Dragan ;

Lopez, Rene ;

Blau, Sibel ;

Collisson, Eric A. ;

Divers, Stephen G. ;

Hoon, Dave S. B. ;

Kopetz, E. Scott ;

Lee, Jeeyun ;

Nikolinakos, Petros G. ;

Baca, Arthur M. ;

Kermani, Bahram G. ;

Eltoukhy, Helmy ;

Talasaz, AmirAli .

PLOS ONE, 2015, 10 (10)

[10] Prediction and Prioritization of Rare Oncogenic Mutations in the Cancer Kinome Using Novel Features and Multiple Classifiers [J].

ManChon, U. ;

Talevich, Eric ;

Katiyar, Samiksha ;

Rasheed, Khaled ;

Kannan, Natarajan .

PLOS COMPUTATIONAL BIOLOGY, 2014, 10 (04)

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