An Efficient Protocol for the Synthesis of Pyrazolo[1,5-c]quinazolines by a Staudinger-Aza-Wittig-Dehydroaromatization Sequence

被引：4
|
作者：
Xu, Mingxian [1 ]
Chen, An [1 ]
Ren, Zhilin [1 ]
Qiu, Jiying [1 ]
Zu, Mingming [1 ]
Zhang, Yi [1 ]
Wang, Jiayi [1 ]
He, Ping [1 ]
机构：
[1] Hubei Univ Arts & Sci, Coll Chem Engn, Xiangyang 441053, Hubei, Peoples R China
来源：
SYNLETT | 2021年 / 32卷 / 18期
关键词：
azidodihydropyrazoles; aza-Wittig reaction; Staudinger reaction; cascade reaction; dehydroaromatization; pyrazoloquinazolines; BIOLOGICAL EVALUATION; RECEPTOR ANTAGONISTS; 3+2 CYCLOADDITION; DERIVATIVES; INHIBITORS; CONSTRUCTION;
D O I：
10.1055/a-1579-1692
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The one-pot synthesis of azide-substituted dihydropyrazoles in isopropanol was performed by using chalcones, hydrazine hydrate, and an acyl chloride at 0 celcius. Subsequent Staudinger-aza-Wittig-dehydroaromatization reactions of the products with methyl(diphenyl)phosphine were also investigated for further application in the construction of pyrazolo[1,5- c ]quinazolines.
引用
收藏
页码：1874 / 1878
页数：5
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