In situ antitumor vaccination: Targeting the tumor microenvironment

被引：26

作者：

Li, Hanwen ^{[1
,2
]}

Yu, Jiayun ^{[1
,2
]}

Wu, Yongyao ^{[1
,2
]}

Shao, Bin ^{[1
,2
]}

Wei, Xiawei ^{[1
,2
]}

机构：

[1] Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, State Key Lab Oral Dis, Chengdu 610041, Peoples R China

[2] Sichuan Univ, Canc Ctr, State Key Lab Biotherapy, Chengdu, Peoples R China

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2020年 / 235卷 / 7-8期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

immunotherapy; intratumoral injection; tumor microenvironment; INTRA-LESIONAL INJECTION; INTRATUMORAL INJECTION; DENDRITIC CELLS; IMMUNE-RESPONSE; T-CELLS; PLASMID DNA; ENZYME A20; HIGH-RISK; CANCER; REGRESSION;

D O I：

10.1002/jcp.29551

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tumor microenvironment is known to play important roles in tumor progression. Many therapies, targeting the tumor microenvironment, are designed and applied in the clinic. One of these approaches is in situ antitumor therapy. This way, bacteria, antibodies, plasmid DNA, viruses, and cells are intratumorally delivered into the tumor site as "in-situ antitumor vaccine," which seeks to enhance immunogenicity and generate systemic T cell responses. In addition, this intratumoral therapy can alter the tumor microenvironment from immunosuppressive to immunostimulatory while limiting the risk of systemic exposure and associated toxicity. Contemporarily, promising preclinical results and some initial success in clinical trials have been obtained after intratumoral therapy.

引用

页码：5490 / 5500

页数：11

共 116 条

[1] Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity [J].

Adusumilli, Prasad S. ;

Cherkassky, Leonid ;

Villena-Vargas, Jonathan ;

Colovos, Christos ;

Servais, Elliot ;

Plotkin, Jason ;

Jones, David R. ;

Sadelain, Michel .

SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (261)

[2] Stathmin overexpression identifies high risk for lymphatic metastatic recurrence in pN0 esophageal squamous cell carcinoma patients [J].

Akhtar, Javed ;

Wang, Zhou ;

Jiang, Wen Peng ;

Bi, Ming Ming ;

Zhang, Zhi Ping .

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2014, 29 (05) :944-950

[3] Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma [J].

Andtbacka, Robert H. I. ;

Kaufman, Howard L. ;

Collichio, Frances ;

Amatruda, Thomas ;

Senzer, Neil ;

Chesney, Jason ;

Delman, Keith A. ;

Spitler, Lynn E. ;

Puzanov, Igor ;

Agarwala, Sanjiv S. ;

Milhem, Mohammed ;

Cranmer, Lee ;

Curti, Brendan ;

Lewis, Karl ;

Ross, Merrick ;

Guthrie, Troy ;

Linette, Gerald P. ;

Daniels, Gregory A. ;

Harrington, Kevin ;

Middleton, Mark R. ;

Miller, Wilson H., Jr. ;

Zager, Jonathan S. ;

Ye, Yining ;

Yao, Bin ;

Li, Ai ;

Doleman, Susan ;

VanderWalde, Ari ;

Gansert, Jennifer ;

Coffin, Robert S. .

JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (25) :2780-U98

[4] Photodynamic therapy versus topical imiquimod versus topical fluorouracil for treatment of superficial basal-cell carcinoma: a single blind, non-inferiority, randomised controlled trial [J].

Arits, Aimee H. M. M. ;

Mosterd, Klara ;

Essers, Brigitte A. B. ;

Spoorenberg, Eefje ;

Sommer, Anja ;

De Rooij, Michette J. M. ;

van Pelt, Han P. A. ;

Quaedvlieg, Patricia J. F. ;

Krekels, Gertruud A. M. ;

van Neer, Pierre A. F. A. ;

Rijzewijk, Joris J. ;

van Geest, Adrienne J. ;

Steijlen, Peter M. ;

Nelemans, Patty J. ;

Kelleners-Smeets, Nicole W. J. .

LANCET ONCOLOGY, 2013, 14 (07) :647-654

[5] Immune-Mediated Regression of Established B16F10 Melanoma by Intratumoral Injection of Attenuated Toxoplasma gondii Protects against Rechallenge [J].

Baird, Jason R. ;

Byrne, Katelyn T. ;

Lizotte, Patrick H. ;

Toraya-Brown, Seiko ;

Scarlett, Uciane K. ;

Alexander, Matthew P. ;

Sheen, Mee Rie ;

Fox, Barbara A. ;

Bzik, David J. ;

Bosenberg, Marcus ;

Mullins, David W. ;

Turk, Mary Jo ;

Fiering, Steven .

JOURNAL OF IMMUNOLOGY, 2013, 190 (01) :469-478

[6] Phase 1 Trial of Bi-shRNA STMN1 BIV in Refractory Cancer [J].

Barve, Minal ;

Wang, Zhaohui ;

Kumar, Padmasini ;

Jay, Christopher M. ;

Luo, Xiuquan ;

Bedell, Cynthia ;

Mennel, Robert G. ;

Wallraven, Gladice ;

Brunicardi, Francis Charles ;

Senzer, Neil ;

Nemunaitis, John ;

Rao, Donald D. .

MOLECULAR THERAPY, 2015, 23 (06) :1123-1130

[7] Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4 [J].

Beck, Kimberly E. ;

Blansfield, Joseph A. ;

Tran, Khoi Q. ;

Feldman, Andrew L. ;

Hughes, Marybeth S. ;

Royal, Richard E. ;

Kammula, Udai S. ;

Topalian, Suzanne L. ;

Sherry, Richard M. ;

Kleiner, David ;

Quezado, Martha ;

Lowy, Israel ;

Yellin, Michael ;

Rosenberg, Steven A. ;

Yang, James C. .

JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (15) :2283-2289

[8] Intratumoral G100, a TLR4 Agonist, Induces Antitumor Immune Responses and Tumor Regression in Patients with Merkel Cell Carcinoma [J].

Bhatia, Shailender ;

Miller, Natalie J. ;

Lu, Hailing ;

Longino, Natalie V. ;

Ibrani, Dafina ;

Shinohara, Michi M. ;

Byrd, David R. ;

Parvathaneni, Upendra ;

Kulikauskas, Rima ;

ter Meulen, Jan ;

Hsu, Frank J. ;

Koelle, David M. ;

Nghiem, Paul .

CLINICAL CANCER RESEARCH, 2019, 25 (04) :1185-1195

[9] Expression of Toll-Like Receptors on Breast Tumors: Taking a Toll on Tumor Microenvironment [J].

Bhattacharya, Debika ;

Yusuf, Nabiha .

INTERNATIONAL JOURNAL OF BREAST CANCER, 2012, 2012

[10] E-cadherin expression on multiple myeloma cells activates tumor-promoting properties in plasmacytoid DCs [J].

Bi, Enguang ;

Li, Rong ;

Bover, Laura C. ;

Li, Haiyan ;

Su, Pan ;

Ma, Xingzhe ;

Huang, Chunjian ;

Wang, Qiang ;

Liu, Lintao ;

Yang, Maojie ;

Lin, Zhijuan ;

Qian, Jianfei ;

Fu, Weijun ;

Liu, Yong-Jun ;

Yi, Qing .

JOURNAL OF CLINICAL INVESTIGATION, 2018, 128 (11) :4821-4831

← 1 2 3 4 5 6 7 8 9 10 →