Emerging roles of the 26S proteasome in nuclear hormone receptor-regulated transcription

被引：10
作者：
Keppler, Brian R. [1 ]
Archer, Trevor K. [1 ]
Kinyamu, H. Karimi [1 ]
机构：
[1] NIEHS, Chromatin & Gene Express Sect, Mol Carcinogenesis Lab, NIH, Res Triangle Pk, NC 27709 USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2011年 / 1809卷 / 02期
关键词：
Proteasome; Nuclear hormone receptor; Transcription; Chromatin; RNA-POLYMERASE-II; CHROMATIN-REMODELING COMPLEX; GLUCOCORTICOID-RECEPTOR; TARGET GENES; DEPENDENT TRANSCRIPTION; SUBUNIT; PROTEIN; COACTIVATOR; DEGRADATION; RECRUITMENT;
D O I：
10.1016/j.bbagrm.2010.08.005
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The mechanisms by which nuclear hormone receptors (NHRs) regulate transcription are highly dynamic and require interplay between a myriad of regulatory protein complexes including the 26S proteasome. Protein degradation is the most well-established role of the proteasome; however, an increasing body of evidence suggests that the 26S proteasome may regulate transcription in proteolytic and nonproteolytic mechanisms. Here we review how these mechanisms may apply to NHR-mediated transcriptional regulation. This article is part of a Special Issue entitled The 26S Proteasome: When degradation is just not enough! Published by Elsevier B.V.
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页码：109 / 118
页数：10
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