Diaryl Ether Formation in the Synthesis of Natural Products

被引：145

作者：

Pitsinos, Emmanuel N. ^{[1
]}

Vidali, Veroniki P. ^{[1
]}

Couladouros, Elias A. ^{[1
,2
]}

机构：

[1] NCSR Demokritos, Nat Prod Synth & Bioorgan Chem Lab, Inst Phys Chem, Aghia Paraskevi 15310, Greece

[2] Agr Univ Athens, Chem Labs, Athens 11855, Greece

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 2011卷 / 07期

关键词：

Natural products; Synthetic methods; Total synthesis; Aromatic substitution; Oxygen heterocycles; Cross-coupling; Diaryl ethers; ARENE-RUTHENIUM CHEMISTRY; EFFICIENT TOTAL-SYNTHESIS; CYCLIC PEPTIDE MODEL; POLYBROMINATED DIPHENYL ETHERS; 1ST TOTAL-SYNTHESIS; DEF RING-SYSTEM; CATALYTIC C-C; RISTOCETIN-A; MACROCYCLIC BIS(BIBENZYL); COMBRETASTATIN D-2;

D O I：

10.1002/ejoc.201001520

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The structural variety of naturally occurring diaryl ethers is illustrated and the various synthetic methods employed for the construction of diaryl ether linkages in related total syntheses are reviewed. Examples of successful applications of each method (including reaction conditions, diaryl ether substitution pattern, and, when appropriate, the size of the ring formed) are given in tabular format.

引用

页码：1207 / 1222

页数：16

共 250 条

[1] Regioselective Synthesis of Functionalized Biaryls Based on the First [3+3] Cyclocondensations of 4-Aryl-1,3-bis(trimethylsilyloxy)buta-1,3-dienes [J].