Activatable Fluorescence Probes for "Turn-On" and Ratiometric Biosensing and Bioimaging: From NIR-I to NIR-II

被引:155
作者
Chen, Chuan [3 ]
Tian, Rui [1 ,2 ]
Zeng, Yun [3 ]
Chu, Chengchao [1 ,2 ]
Liu, Gang [1 ,2 ]
机构
[1] Xiamen Univ, Sch Publ Hlth, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen 361102, Peoples R China
[2] Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, Xiamen 361102, Peoples R China
[3] Xiamen Med Coll, Dept Pharm, Xiamen 361023, Peoples R China
基金
中国国家自然科学基金;
关键词
AGGREGATION-INDUCED EMISSION; NEAR-INFRARED WINDOW; AG2S QUANTUM DOTS; CARBON NANOTUBES; BETA-GALACTOSIDASE; FLUOROGENIC PROBE; TUNABLE EMISSION; RATIONAL DESIGN; REACTIVE OXYGEN; VIVO;
D O I
10.1021/acs.bioconjchem.9b00734
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The greatest advantage of activatable fluorescence probes (AFPs) is the inherent responsiveness to manipulate spectroscopic properties by chemical/physical interactions with the biological analytes/microenvironmental factors. As alternatives to "always-on" fluorescence probes, AFPs in the first near-infrared (NIR-I) window expanded dramatically over the past decade and served as powerful tools in fluorescence biosensing and bioimaging. Benefiting from the deep tissue penetration, minimal tissue damage, and negligible background signal within longer wavelength, recent progress of fluorescent materials in the second near-infrared (NIR-II) window has been creating vast new opportunities in developing AFPs. Here, we review the current role of AFPs in biosensing and bioimaging, with emphasis on NIR-II AFPs developed for biomedical applications. The challenges and prospects of AFPs are also discussed by considering the clinical translation from bench to bedside.
引用
收藏
页码:276 / 292
页数:17
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