Metabolic switching and cell fate decisions: implications for pluripotency, reprogramming and development

被引：69

作者：

Cliff, Tim S.

Dalton, Stephen ^{[1
]}

机构：

[1] Univ Georgia, Dept Biochem & Mol Biol, 500 DW Brooks Dr, Athens, GA 30602 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2017年 / 46卷

基金：

美国国家卫生研究院;

关键词：

GLYCOLYTIC METABOLISM; OSTEOGENIC DIFFERENTIATION; MITOCHONDRIAL BIOGENESIS; GLUTAMINE-METABOLISM; OXIDATIVE STRESS; SOMATIC-CELLS; STEM-CELLS; HYPOXIA; EPIGENETICS; INDUCTION;

D O I：

10.1016/j.gde.2017.06.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cell fate decisions are closely linked to changes in metabolic activity. Over recent years this connection has been implicated in mechanisms underpinning embryonic development, reprogramming and disease pathogenesis. In addition to being important for supporting the energy demands of different cell types, metabolic switching from aerobic glycolysis to oxidative phosphorylation plays a critical role in controlling biosynthetic processes, intracellular redox state, epigenetic status and reactive oxygen species levels. These processes extend beyond ATP synthesis by impacting cell proliferation, differentiation, enzymatic activity, ageing and genomic integrity. This review will focus on how metabolic switching impacts decisions made by multipotent cells and discusses mechanisms by which this occurs.

引用

页码：44 / 49

页数：6

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