Synthesis and characterization of polyamidoamine conjugates of neridronic acid

被引：9

作者：

Aderibigbe, B. A. ^{[1
]}

Sadiku, E. R. ^{[2
]}

Ray, S. Sinha ^{[3
,4
]}

Mbianda, X. Y. ^{[4
]}

Fotsing, M. C. ^{[4
]}

Agwuncha, S. C. ^{[2
]}

Owonubi, S. J. ^{[2
]}

机构：

[1] Univ Ft Hare, Dept Chem, Eastern Cape, South Africa

[2] Tshwane Univ Technol, Dept Chem Met & Mat Engn, Pretoria, South Africa

[3] CSIR, Natl Ctr Nanostruct Mat, ZA-0001 Pretoria, South Africa

[4] Univ Johannesburg, Dept Chem Technol, Johannesburg, South Africa

来源：

POLYMER BULLETIN | 2015年 / 72卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

Neridronic acid; Polyamidoamines; Polymeric conjugates; Michael addition; Anticancer; NITROGEN-CONTAINING BISPHOSPHONATES; AMINO-GROUPS; POLYMERS; THERAPY;

D O I：

10.1007/s00289-014-1286-z

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Polyamidoamine conjugates of neridronic acid were synthesized by a one-pot aqueous phase Michael addition reaction of N, N'-methylenebisacrylamide with selected primary and secondary amines and neridronic acid. This reaction involved the use of water and it was performed at room temperature thereby making the reaction environmentally friendly and economically viable. These conjugates are potential prodrugs and they were characterized by nuclear magnetic resonance spectroscopy (NMR), Fourier transform spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscope (SEM) and energy-dispersive X-ray analysis (EDX). NMR, TGA, XRD and FTIR confirmed the successful incorporation of the bisphosphonate on to the carriers. The mass percentage incorporation of neridronic acid was found to be between 0.9 and 3.74 percent. P-31 NMR exhibited the signal peak for the bisphosphonate at 19.0 ppm.

引用

页码：417 / 439

页数：23

共 37 条

[1]

Agrawal RN, 2013, J ANTIVIR ANTIRETR S, VS15, P12

[2] Poly(ethylene glycol)-Prodrug Conjugates: Concept, Design, and Applications [J].

Banerjee, Shashwat S. ;

Aher, Naval ;

Patil, Rajesh ;

Khandare, Jayant .

JOURNAL OF DRUG DELIVERY, 2012, 2012

[3]

Barbucci R, 2008, Eur Patent Application, Patent No. [EP 1 994 945 A1, 1994945]

[4]

Bentley M.D., 1999, P.C.T., Patent No. [US99/23536, 9923536]

[5] SYNTHESIS OF WATER-SOLUBLE POLYAMIDOAMINES FOR BIOMEDICAL APPLICATIONS .2. POLYMERS POSSESSING INTRACHAIN-TYPE SECONDARY AMINO-GROUPS SUITABLE FOR SIDE-CHAIN ATTACHMENT [J].

CALDWELL, G ;

NEUSE, EW ;

STEPHANOU, A .

JOURNAL OF APPLIED POLYMER SCIENCE, 1993, 50 (03) :393-401

[6] Poly(amidoamine)-Cholesterol Conjugate Nanoparticles Obtained by Electrospraying as Novel Tamoxifen Delivery System [J].

Cavalli, R. ;

Bisazza, A. ;

Bussano, R. ;

Trotta, M. ;

Civra, A. ;

Lembo, D. ;

Ranucci, E. ;

Ferruti, P. .

JOURNAL OF DRUG DELIVERY, 2011, 2011

[7]

da Silva FM, 2001, J BRAZ CHEM SOC, V12

[8] SYNTHESIS OF TERTIARY AMINE POLYMERS [J].

DANUSSO, F ;

FERRUTI, P .

POLYMER, 1970, 11 (02) :88-&

[9]

Dunford JE, 2010, CURR PHARM DESIGN, V16, P2961

[10]

Ferruti P, 2002, MACROMOL RAPID COMM, V23, P332, DOI 10.1002/1521-3927(20020401)23:5/6<332::AID-MARC332>3.0.CO

← 1 2 3 4 →