Vitamin D Receptor Gene Polymorphism and Vitamin D Status in Population of Patients with Cardiovascular Disease-A Preliminary Study

被引:30
作者
Abouzid, Mohamed [1 ]
Kruszyna, Marlena [2 ]
Burchardt, Pawel [2 ,3 ]
Kruszyna, Lukasz [4 ]
Glowka, Franciszek K. [1 ]
Karazniewicz-Lada, Marta [1 ]
机构
[1] Poznan Univ Med Sci, Dept Phys Pharm & Pharmacokinet, 6 Swiecickiego St, PL-60781 Poznan, Poland
[2] Poznan Univ Med Sci, Dept Hypertens Angiol & Internal Med, Dluga 1-2, PL-60848 Poznan, Poland
[3] J Stru Hosp, Dept Cardiol, Szwajcarska 3, PL-61285 Poznan, Poland
[4] Poznan Univ Med Sci, Dept Vasc & Endovasc Surg, Angiol & Phlebol, Dluga 1-2, PL-60848 Poznan, Poland
关键词
ApaI; BsmI; FokI; TaqI; hypertension; obesity; 25-hydroxyvitamin D; epi-25-hydroxyvitamin D; CORONARY-ARTERY-DISEASE; 25-HYDROXYVITAMIN D; PARATHYROID-HORMONE; D DEFICIENCY; ENDOTHELIAL DYSFUNCTION; COMMON VARIANTS; HEART-DISEASE; D METABOLISM; VDR GENE; ASSOCIATION;
D O I
10.3390/nu13093117
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The association between vitamin D receptor (VDR) polymorphism and the risk of cardiovascular diseases (CVD) remains unclear. This study aimed to assess a relationship between the VDR genotypes, plasma concentrations of vitamin D metabolites, and the occurrence of cardiovascular and metabolic disorders. Fifty-eight patients treated for various cardiological afflictions were included. Identification of VDR polymorphisms: ApaI, TaqI, BsmI, and FokI were carried out using the PCR-RFLP method. Plasma concentrations of 25-hydroxyvitamin-D2, 25-hydroxyvitamin-D3, and 3-epi-25-hydroxyvitamin D3 were assessed by the UPLC-MS/MS method. Lower incidence of BsmI AA genotype in the studied patients was observed compared with healthy controls, but the difference was insignificant. Among patients with the TT genotype, frequency of hypertension was higher than among carriers of other ApaI genotypes (p < 0.01). In addition, carriers of the TT ApaI, TC TaqI, and GA BsmI genotypes had an increased risk of obesity, while the presence of the FokI TT genotype was associated with a higher incidence of heart failure and hypertension. In conclusion, the BsmI AA genotype can be protective against CVD, but this observation needs study on a larger group of patients. Particular VDR genotypes were associated with 25-hydroxyvitamin-D levels, and the mechanism of this association should be further investigated.
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页数:16
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