Peri-Operative Risk Management in Patients with Alzheimer's Disease

被引：12

作者：

Di Nino, Gianfranco ^{[1
]}

Adversi, Marco ^{[1
]}

Dekel, Boaz G. Samolsky ^{[1
]}

Fodale, Vincenzo ^{[2
]}

Rosa, Giovanni ^{[3
]}

Melotti, Rita M. ^{[1
]}

机构：

[1] Univ Bologna, Dept Surg & Anesthesiol Sci, Bologna, Italy

[2] Univ Messina, Dept Neurosci Psychiat & Anesthesiol Sci, Messina, Italy

[3] Univ Roma La Sapienza, Dept Anesthesiol Crit Care & Pain Med Neuroanaest, Rome, Italy

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2010年 / 22卷

关键词：

Alzheimer's disease; anesthesia; anesthetics; delirium; dementia; pain; pain measurement; POCD; postoperative; POSTOPERATIVE COGNITIVE DYSFUNCTION; AMYLOID-BETA-PEPTIDE; CLINICALLY RELEVANT CONCENTRATIONS; ANESTHETICS; HALOTHANE; OLIGOMERIZATION; ISOFLURANE; PROPOFOL; DELIRIUM; SURGERY;

D O I：

10.3233/JAD-2010-101299

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The aim of this review is to identify an evidence-based perioperative management for patients affected by Alzheimer's disease (AD) that are scheduled to undergo surgery. This will minimize the negative effects of anesthesia and postoperative sedation and correct those perioperative variables possibly responsible for a decline in cognitive status and a worsening of AD. We here gather evidence on the importance of correct preoperative assessment regarding cognitive and functional status and the presence of preoperative delirium. The potential role of anesthesia, surgery, and postoperative analgosedation as risk factors for development of delirium are herein outlined. Finally, pain assessment instruments, as well as principles of management strategies for postoperative delirium in subjects with AD, are suggested.

引用

页码：S121 / S127

页数：7

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