Sex Differences and the Risk of Kidney Stones

被引：21
作者：
Ferraro, Pietro Manuel [1 ,2 ]
Cunha, Tamara da Silva [3 ]
Curhan, Gary C. [4 ]
机构：
[1] Fdn Policlin Univ A Gemelli IRCCS, UOS Terapia Conservat Malattia Renale Cron, Rome, Italy
[2] Univ Cattolica Sacro Cuore, Dipartimento Univ Med & Chirurg Traslaz, Rome, Italy
[3] Univ Fed Rio de Janeiro, Nephrol Div, Rio De Janeiro, Brazil
[4] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA
来源：
SEMINARS IN NEPHROLOGY | 2022年 / 42卷 / 02期
关键词：
Kidney stones; diet; sex hormones; nephrolithiasis; ANOREXIA-NERVOSA; POSTMENOPAUSAL WOMEN; METABOLIC SYNDROME; NATIONAL-HEALTH; LAXATIVE ABUSE; UNITED-STATES; URINE PH; PREVALENCE; UROLITHIASIS; NEPHROLITHIASIS;
D O I：
10.1016/j.semnephrol.2022.04.012
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
A significant increase in the prevalence of kidney stones has been observed worldwide. In the past decades, this expansion was more pronounced among women than men. The precise mechanisms involved in the differences in the risk profile of stone disease between men and women have not been fully elucidated. Diet and lifestyle only partially can explain the differences, and the combination of factors such as the influence of sex hormones, genetics, and disorders in acid-base handling and urine pH, as well as differences in calcium tubular reabsorption and stone composition in men and women, may contribute to differences in the risk profile. In this review, we summarize the sex differences in the pathophysiologic basis of kidney stones, which may contribute to a more focused approach. (C) Elsevier Inc. All rights reserved.
引用
收藏
页码：230 / 235
页数：6
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