Adiposity and plane of nutrition influence reproductive neuroendocrine and appetite responses to intracerebroventricular insulin and neuropeptide-Y in sheep

被引:5
作者
Miller, D. W. [1 ]
Bennett, E. J. [2 ,3 ]
Harrison, J. L. [1 ,2 ,4 ]
Findlay, P. A. [2 ]
Adam, C. L. [2 ]
机构
[1] Murdoch Univ, Sch Vet & Biomed Sci, Murdoch, WA 6150, Australia
[2] Univ Aberdeen, Obes & Metab Hlth Div, Rowett Inst Nutr & Hlth, Aberdeen AB21 9SB, Scotland
[3] Scottish Agr Coll, Sustainable Livestock Syst Grp, Aberdeen AB21 9YA, Scotland
[4] Univ Aberdeen, Sch Biol Sci, Aberdeen AB24 2TZ, Scotland
基金
英国生物技术与生命科学研究理事会;
关键词
body fat; food intake; GnRH; hypothalamus; LH; LUTEINIZING-HORMONE SECRETION; LH-SECRETION; GENE-EXPRESSION; FOOD-INTAKE; GONADOTROPIN-SECRETION; BODY-FAT; LEPTIN; GNRH; PROOPIOMELANOCORTIN; RESTRICTION;
D O I
10.1071/RD10150
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Long-term nutritional background is thought to influence hypothalamic appetite and reproductive neuroendocrine responses to short-term nutritional feedback. In order to investigate this phenomenon, the effects of intracerebroventricular administration of insulin or neuropeptide-Y (NPY) on LH secretion and voluntary food intake (VFI) were examined in sheep that were initially thin and kept on an increasing nutritional plane (INP), or initially fat and kept on a decreasing nutritional plane (DNP), for 10 weeks. Intracerebroventricular insulin stimulated LH secretion and suppressed VFI in INP sheep when initially thin, but not when they became fat, and had no effect on LH in DNP sheep when initially fat, and stimulated LH secretion when they became thin. Intracerebroventricular NPY had no effect on LH or VFI in INP sheep when initially thin, decreased LH secretion and increased VFI when they became fat, and decreased LH secretion in DNP sheep when initially fat but had no effect when they became thin. Therefore, sensitivity to insulin increases with low or decreasing nutritional status and decreases with high or increasing nutritional status, whereas sensitivity to NPY increases with high or increasing nutritional status and decreases with low or decreasing nutritional status. In conclusion, reproductive neuroendocrine and appetite responses to acute changes in nutritional feedback signals depend on the individual's longer-term nutritional background.
引用
收藏
页码:329 / 338
页数:10
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