Robust ordering of independent components in functional magnetic resonance imaging time series data using canonical correlation analysis

The application of independent components analysis (ICA) to functional magnetic resonance imaging data has been,proven useful to decompose the signal in terms of its basic sources. The main advantage is that ICA requires no prior assumption about the neuronal activity or the noise structure, which are. usually unknown in fMRI This enables the detection of true activation components free of random and physiological noise. Hence, this technique is superior to other techniques such as subspace modeling or canonical correlation analysis, which have underlying assumptions about the signal components. Nevertheless, this technique suffers from a fundamental limitation of not providing a consistent ordering of the signal components as a result of the whitening step involved in ICA. This mandates human intervention to pick out the relevant activation components from the outcome of ICA, which poses a significant obstacle to the practicality of this technique. In this work, a simple yet robust technique is proposed for ranking the resultant independent components. This technique adds a second step to ICA based on canonical correlation analysis and the prior information about the activation paradigm. This enables the proposed technique to provide a consistent and reproducible ordering of independent components. The proposed technique was applied to real event-related functional magnetic resonance imaging data and the results confirm the practicality and robustness of the proposed method.