Transplant of SARS-CoV-2-infected Living Donor Liver: Case Report

被引:13
作者
Nguyen, Michelle C. [1 ]
Lee, Eliza J. [1 ]
Avery, Robin K. [2 ]
Dioverti-Prono, M. Veronica [2 ]
Shoham, Shmuel [2 ]
Tobian, Aaron A. R. [3 ]
Bloch, Evan M. [3 ]
Gurakar, Ahmet [4 ]
Rizkalla, Nicole A. [5 ]
Cameron, Andrew M. [1 ,6 ]
King, Elizabeth A. [1 ]
Ottmann, Shane [1 ]
Garonzik-Wang, Jacqueline M. [1 ,6 ]
Wesson, Russel N. [1 ]
Philosophe, Benjamin [1 ]
机构
[1] Johns Hopkins Univ, Sch Med, Dept Surg, Div Transplant Surg, Baltimore, MD 21205 USA
[2] Johns Hopkins Univ, Sch Med, Dept Med, Div Infect Dis, Baltimore, MD 21205 USA
[3] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA
[4] Johns Hopkins Univ, Sch Med, Dept Med, Div Gastroenterol & Hepatol, Baltimore, MD 21205 USA
[5] Johns Hopkins Univ, Sch Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21205 USA
[6] Johns Hopkins Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA
来源
TRANSPLANTATION DIRECT | 2021年 / 7卷 / 08期
关键词
SOLID-ORGAN TRANSPLANTATION; EARLY IMPACT; COVID-19;
D O I
10.1097/TXD.0000000000001178
中图分类号
R3 [基础医学]; R4 [临床医学];
学科分类号
1001 ; 1002 ; 100602 ;
摘要
Given the high community prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), transplant programs will encounter SARS-CoV-2 infections in living donors or recipients in the perioperative period. There is limited data on SARS-CoV-2 viremia and organotropism beyond the respiratory tract to inform the risk of transplant transmission of SARS-CoV-2. We report a case of a living donor liver transplant recipient who received a right lobe graft from a living donor with symptomatic PCR-confirmed SARS-CoV-2 infection 3 d following donation. The donor was successfully treated with remdesivir, dexamethasone, and coronavirus disease 2019 (COVID-19) convalescent plasma. No viral transmission was identified, and both donor and recipient had excellent postoperative outcomes.
引用
收藏
页数:5
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