Regulation of ion channels by cAMP-dependent protein kinase and A-kinase anchoring proteins

被引：145
作者：
Gray, PC [1 ]
Scott, JD
Catterall, WA
机构：
[1] Univ Washington, Dept Pharmacol, Seattle, WA 98195 USA
[2] Oregon Hlth & Sci Univ, Vollum Inst, Howard Hughes Med Inst, Portland, OR 97201 USA
来源：
CURRENT OPINION IN NEUROBIOLOGY | 1998年 / 8卷 / 03期
关键词：
D O I：
10.1016/S0959-4388(98)80057-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Subcellular targeting of the cAMP-dependent protein kinase is achieved, in part, through association with A-kinase anchoring proteins (AKAPs). Recent evidence suggests that specific AKAPs direct the kinase to submembrane sites to facilitate phosphorylation and modulation of a variety of ion channels. A new membrane-anchored AKAP targets cAMP-dependent protein kinase to calcium channels and enhances their regulation in multiple cell types.
引用
收藏
页码：330 / 334
页数：5
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