An efficient ultrasonic-mediated one-pot synthesis of 2,3,6,7,9-pentaazabicyclo[3.3.1]nonanes via a N,N-dimethylformamide dimethylacetal catalyzed Mannich-like reaction

被引：7
作者：
Behbehani, Haider [1 ]
Ibrahim, Hamada Mohamed [1 ]
机构：
[1] Kuwait Univ, Fac Sci, Dept Chem, POB 5969, Safat 13060, Kuwait
来源：
RSC ADVANCES | 2016年 / 6卷 / 58期
关键词：
4+1 CYCLOADDITION; DERIVATIVES; CHEMISTRY;
D O I：
10.1039/c6ra09210a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel and straightforward method for one-pot synthesis of functionalized 2,3,6,7,9-pentaazabicyclo[3.3.1]nonane derivatives has been developed. The process, which involves ultrasonic irradiation promoted Mannich reaction between 3-oxo-2-arylhydrazonopropanals and ammonia in acetic acid, is catalyzed by N,N-dimethylformamide dimethylacetal (DMF-DMA) and generates the target products in 80-93% yields.
引用
收藏
页码：52700 / 52709
页数：10
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