An efficient ultrasonic-mediated one-pot synthesis of 2,3,6,7,9-pentaazabicyclo[3.3.1]nonanes via a N,N-dimethylformamide dimethylacetal catalyzed Mannich-like reaction

被引：8

作者：

Behbehani, Haider ^{[1
]}

Ibrahim, Hamada Mohamed ^{[1
]}

机构：

[1] Kuwait Univ, Fac Sci, Dept Chem, POB 5969, Safat 13060, Kuwait

来源：

RSC ADVANCES | 2016年 / 6卷 / 58期

关键词：

4+1 CYCLOADDITION; DERIVATIVES; CHEMISTRY;

D O I：

10.1039/c6ra09210a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel and straightforward method for one-pot synthesis of functionalized 2,3,6,7,9-pentaazabicyclo[3.3.1]nonane derivatives has been developed. The process, which involves ultrasonic irradiation promoted Mannich reaction between 3-oxo-2-arylhydrazonopropanals and ammonia in acetic acid, is catalyzed by N,N-dimethylformamide dimethylacetal (DMF-DMA) and generates the target products in 80-93% yields.

引用

页码：52700 / 52709

页数：10

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