Regulatory T cells, as a target in anticancer immunotherapy

被引：7

作者：

Enokida, Tomohiro ^{[1
]}

Nishikawa, Hiroyoshi ^{[1
,2
]}

机构：

[1] Natl Canc Ctr, Exploratory Oncol Res & Clin Trial Ctr, Res Inst, Div Canc Immunol, Chiba 2778577, Japan

[2] Nagoya Univ, Grad Sch Med, Dept Immunol, Nagoya, Aichi 4668550, Japan

来源：

IMMUNOTHERAPY | 2017年 / 9卷 / 08期

关键词：

cancer; chemokines; immune check point; immunotherapy; microenvironment; regulatory T cell; CANCER-PATIENTS; IMMUNE-RESPONSES; SELF-TOLERANCE; BREAST-CANCER; SUPPRESSION; DEPLETION; MELANOMA; PEPTIDE;

D O I：

10.2217/imt-2017-0057

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

[No abstract available]

引用

页码：623 / 627

页数：5

共 22 条

[1] Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer [J].

Ali, Khaled ;

Soond, Dalya R. ;

Pineiro, Roberto ;

Hagemann, Thorsten ;

Pearce, Wayne ;

Lim, Ee Lyn ;

Bouabe, Hicham ;

Scudamore, Cheryl L. ;

Hancox, Timothy ;

Maecker, Heather ;

Friedman, Lori ;

Turner, Martin ;

Okkenhaug, Klaus ;

Vanhaesebroeck, Bart .

NATURE, 2014, 510 (7505) :407-+

[2] PD-1 modulates regulatory T-cell homeostasis during low-dose interleukin-2 therapy [J].

Asano, Takeru ;

Meguri, Yusuke ;

Yoshioka, Takanori ;

Kishi, Yuriko ;

Iwamoto, Miki ;

Nakamura, Makoto ;

Sando, Yasuhisa ;

Yagita, Hideo ;

Koreth, John ;

Kim, Haesook T. ;

Alyea, Edwin P. ;

Armand, Philippe ;

Cutler, Corey S. ;

Ho, Vincent T. ;

Antin, Joseph H. ;

Soiffer, Robert J. ;

Maeda, Yoshinobu ;

Tanimoto, Mitsune ;

Ritz, Jerome ;

Matsuoka, Ken-ichi .

BLOOD, 2017, 129 (15) :2186-2197

[3] The Prognostic Value of FoxP3+ Tumor-Infiltrating Lymphocytes in Cancer: A Critical Review of the Literature [J].

deLeeuw, Ronald J. ;

Kost, Sara E. ;

Kakal, Juzer A. ;

Nelson, Brad H. .

CLINICAL CANCER RESEARCH, 2012, 18 (11) :3022-3029

[4] The CD4+ T-Cell Response of Melanoma Patients to a MAGE-A3 Peptide Vaccine Involves Potential Regulatory T Cells [J].

Francois, Violaine ;

Ottaviani, Sabrina ;

Renkvist, Nicolina ;

Stockis, Julie ;

Schuler, Gerold ;

Thielemans, Kris ;

Colau, Didier ;

Marchand, Marie ;

Boon, Thierry ;

Lucas, Sophie ;

van der Bruggen, Pierre .

CANCER RESEARCH, 2009, 69 (10) :4335-4345

[5] Metronomic cyclophosphamide treatment in metastasized breast cancer patients: immunological effects and clinical outcome [J].

Ge, Yingzi ;

Domschke, Christoph ;

Stoiber, Natalija ;

Schott, Sarah ;

Heil, Joerg ;

Rom, Joachim ;

Blumenstein, Maria ;

Thum, Janina ;

Sohn, Christof ;

Schneeweiss, Andreas ;

Beckhove, Philipp ;

Schuetz, Florian .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2012, 61 (03) :353-362

[6] Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide [J].

Jordan, MS ;

Boesteanu, A ;

Reed, AJ ;

Petrone, AL ;

Holenbeck, AE ;

Lerman, MA ;

Naji, A ;

Caton, AJ .

NATURE IMMUNOLOGY, 2001, 2 (04) :301-306

[7] Phase Ia Study of FoxP3+ CD4 Treg Depletion by Infusion of a Humanized Anti-CCR4 Antibody, KW-0761, in Cancer Patients [J].

Kurose, Koji ;

Ohue, Yoshihiro ;

Wada, Hisashi ;

Iida, Shinsuke ;

Ishida, Takashi ;

Kojima, Takashi ;

Doi, Toshihiko ;

Suzuki, Susumu ;

Isobe, Midori ;

Funakoshi, Takeru ;

Kakimi, Kazuhiro ;

Nishikawa, Hiroyoshi ;

Udono, Heiichiro ;

Oka, Mikio ;

Ueda, Ryuzo ;

Nakayama, Eiichi .

CLINICAL CANCER RESEARCH, 2015, 21 (19) :4327-4336

[8] Detection of self-reactive CD8+ T cells with an anergic phenotype in healthy individuals [J].

Maeda, Yuka ;

Nishikawa, Hiroyoshi ;

Sugiyama, Daisuke ;

Ha, Danbee ;

Hamaguchi, Masahide ;

Saito, Takuro ;

Nishioka, Megumi ;

Wing, James B. ;

Adeegbe, Dennis ;

Katayama, Ichiro ;

Sakaguchi, Shimon .

SCIENCE, 2014, 346 (6216) :1536-1540

[9] Regulatory T-cell Trafficking: From Thymic Development to Tumor-Induced Immune Suppression [J].

Mailloux, Adam W. ;

Young, M. Rita I. .

CRITICAL REVIEWS IN IMMUNOLOGY, 2010, 30 (05) :435-447

[10] Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor [J].

Miyara, Makoto ;

Yoshioka, Yumiko ;

Kitoh, Akihiko ;

Shima, Tomoko ;

Wing, Kajsa ;

Niwa, Akira ;

Parizot, Christophe ;

Taflin, Cecile ;

Heike, Toshio ;

Valeyre, Dominique ;

Mathian, Alexis ;

Nakahata, Tatsutoshi ;

Yamaguchi, Tomoyuki ;

Nomura, Takashi ;

Ono, Masahiro ;

Amoura, Zahir ;

Gorochov, Guy ;

Sakaguchi, Shimon .

IMMUNITY, 2009, 30 (06) :899-911

← 1 2 3 →