Chemerin as a Mediator between Obesity and Vascular Inflammation in Children

被引:139
作者
Landgraf, Kathrin [1 ,2 ]
Friebe, Daniela [1 ]
Ullrich, Tina [1 ]
Kratzsch, Juergen [3 ]
Dittrich, Kathrin [1 ]
Herberth, Gunda [4 ]
Adams, Volker [5 ]
Kiess, Wieland [1 ,2 ]
Erbs, Sandra [5 ]
Koerner, Antje [1 ,2 ]
机构
[1] Univ Leipzig, Dept Womens & Child Hlth, Ctr Pediat Res, D-04103 Leipzig, Germany
[2] Univ Leipzig, IFB Adipos Dis, Leipzig Univ Med Ctr, D-04103 Leipzig, Germany
[3] Univ Leipzig, Inst Lab Med Clin Chem & Mol Diagnost, D-04103 Leipzig, Germany
[4] UFZ Helmholtz Ctr Environm Res, Dept Environm Immunol, D-04318 Leipzig, Germany
[5] Univ Leipzig, Dept Cardiol, Ctr Heart, D-04103 Leipzig, Germany
关键词
CIRCULATING ADHESION MOLECULES; HUMAN ENDOTHELIAL-CELLS; METABOLIC SYNDROME; CORONARY ATHEROSCLEROSIS; DISEASE; ADIPOGENESIS; ADIPOKINE; RECEPTOR; ADOLESCENTS; POPULATION;
D O I
10.1210/jc.2011-2937
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Context: The chemoattractant protein chemerin has recently been shown to be expressed in adipose tissue. Objective: We aimed to evaluate the association of chemerin with obesity and early-onset metabolic and vascular sequelae in children. Design: We quantified chemerin serum levels in 69 lean and 105 obese children and assessed associations with metabolic and cardiovascular parameters. In addition, a potential direct effect of chemerin on the expression of endothelial adhesion molecules and cell viability was assessed in human coronary artery endothelial cells in vitro. Results: Chemerin concentrations were significantly higher in obese compared to lean children and correlated with obesity-related parameters such as body mass index SD score, leptin, and skinfold thickness. Moreover, we identified significant associations with the measures of inflammation high-sensitivity C-reactive protein and white blood cell count, as well as with the markers of endothelial activation intercellular adhesion molecule-1 (ICAM-1) and E-selectin. Multiple regression analyses confirmed chemerin as the strongest predictor of ICAM-1 and E-selectin independent of body mass index SD score. Likewise, on the cellular level, chemerin induced ICAM-1 and E-selectin expression in endothelial cells in vitro, whereas VCAM-1 and eNOS expression and endothelial cell viability were unaffected. Conclusion: Our results suggest an association of chemerin with obesity and inflammatory and endothelial activation markers and support a role for chemerin as a molecular link between increasing fat mass and an early atherogenic risk profile in obese children. (J Clin Endocrinol Metab 97: E556-E564, 2012)
引用
收藏
页码:E556 / E564
页数:9
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