Applicability of sheep and pig models for cancellous bone in human vertebral bodies

被引：3

作者：

Aslani, Farnaz Jabbary ^{[1
]}

Hukins, David W. L. ^{[1
]}

Shepherd, Duncan E. T. ^{[1
]}

机构：

[1] Univ Birmingham, Sch Mech Engn, Birmingham, W Midlands, England

来源：

PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE | 2012年 / 226卷 / H1期

关键词：

Animal models; bone mineral; spinal surgery; vertebrae; CORTICAL BONE; SEGMENTS;

D O I：

10.1177/0954411911426807

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The mineral content of cancellous bone from sheep and pig vertebral bodies was determined by ashing at 800 degrees C. The results were compared with published results for human vertebral cancellous bone. The results for sheep (0.37 +/- 0.06 g cm(-3), mean +/- standard deviation) were not significantly different (p=0.127) to those from pigs (0.33 +/- 0.03 g cm(-3)). The results from both species were significantly higher (p<0.001) than those from human bones (0.15 +/- 0.02 g cm(-3)). This means that cancellous bone from sheep and pig vertebral bodies is not a good model for corresponding human bone. However, sheep and pig bone are useful, for example, for providing stringent tests of cutting instruments to be used in human spinal surgery.

引用

页码：76 / 78

页数：3

共 17 条

[1]

[Anonymous], 2015, INTRO MED STAT

[2] STIFFENING EFFECTS OF CORTICAL BONE ON VERTEBRAL CANCELLOUS BONE IN-SITU [J].

BRYCE, R ;

ASPDEN, RM ;

WYTCH, R .

SPINE, 1995, 20 (09) :999-1003

[3] Material properties of subchondral bone from patients with osteoporosis or osteoarthritis by microindentation testing and electron probe microanalysis [J].

Coats, AM ;

Zioupos, P ;

Aspden, RM .

CALCIFIED TISSUE INTERNATIONAL, 2003, 73 (01) :66-71

[4] RELATIONSHIP BETWEEN STIFFNESS AND MINERAL CONTENT OF BONE [J].

CURREY, JD .

JOURNAL OF BIOMECHANICS, 1969, 2 (04) :477-&

[5] COMPOSITION OF TRABECULAR + CORTICAL BONE [J].

GONG, JK ;

ARNOLD, JS ;

COHN, SH .

ANATOMICAL RECORD, 1964, 149 (03) :325-&

[6] ULTRAHIGH-RESOLUTION X-RAY TOMOGRAPHY [J].

HADDAD, WS ;

MCNULTY, I ;

TREBES, JE ;

ANDERSON, EH ;

LEVESQUE, RA ;

YANG, L .

SCIENCE, 1994, 266 (5188) :1213-1215

[7] END-PLATE DISPLACEMENT DURING COMPRESSION OF LUMBAR VERTEBRA DISK VERTEBRA SEGMENTS AND THE MECHANISM OF FAILURE [J].

HOLMES, AD ;

HUKINS, DWL ;

FREEMONT, AJ .

SPINE, 1993, 18 (01) :128-135

[8]

Jabbary Aslani F, J ENG MED IN PRESS

[9] Are the spines of calf, pig and sheep suitable models for pre-clinical implant tests? [J].

Kettler, A. ;

Liakos, L. ;

Haegele, B. ;

Wilke, H. -J. .

EUROPEAN SPINE JOURNAL, 2007, 16 (12) :2186-2192

[10] Effect of the proportion of organic material in bone on thermal decomposition of bone mineral: An investigation of a variety of bones from different species using thermogravimetric analysis coupled to mass spectrometry, high-temperature X-ray diffraction, and Fourier transform infrared spectroscopy [J].

Mkukuma, LD ;

Skakle, JMS ;

Gibson, IR ;

Imrie, CT ;

Aspden, RM ;

Hukins, DWL .

CALCIFIED TISSUE INTERNATIONAL, 2004, 75 (04) :321-328

← 1 2 →