Anti-myelin antibodies do not allow earlier diagnosis of multiple sclerosis

被引：61

作者：

Lim, ET

Berger, T

Reindl, M

Dalton, CM

Fernando, K

Keir, G

Thompson, EJ

Miller, DH

Giovannoni, G

机构：

[1] UCL, Inst Neurol, Dept Neuroinflammat, MS NMR Res Unit, London WC1N 3BG, England

[2] Innsbruck Med Univ, Dept Clin Neurol, A-6020 Innsbruck, Austria

来源：

MULTIPLE SCLEROSIS JOURNAL | 2005年 / 11卷 / 04期

关键词：

anti-myelin antibodies; clinically isolated syndrome; multiple sclerosis;

D O I：

10.1191/1352458505ms1187sr

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This study investigates whether the presence of serum and plasma anti-myelin oligodendrocyte glycoprotein (MOG) and anti-myelin basic protein (MBP) in patients presenting with a clinically isolated syndrome compatible with demyelination (CIS) predicts early conversion to multiple sclerosis (MS). Forty-seven patients with CIS (46 with optic neuritis) had anti-MOG and anti-MBP antibodies analysed at baseline, and clinical and magnetic resonance imaging assessments. There was no evidence that the MS status based on either the McDonald or Poser criteria relates to the antibody status.

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页码：492 / 494

页数：3

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