Anti-myelin antibodies do not allow earlier diagnosis of multiple sclerosis

被引：61
作者：
Lim, ET
Berger, T
Reindl, M
Dalton, CM
Fernando, K
Keir, G
Thompson, EJ
Miller, DH
Giovannoni, G
机构：
[1] UCL, Inst Neurol, Dept Neuroinflammat, MS NMR Res Unit, London WC1N 3BG, England
[2] Innsbruck Med Univ, Dept Clin Neurol, A-6020 Innsbruck, Austria
来源：
MULTIPLE SCLEROSIS JOURNAL | 2005年 / 11卷 / 04期
关键词：
anti-myelin antibodies; clinically isolated syndrome; multiple sclerosis;
D O I：
10.1191/1352458505ms1187sr
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
This study investigates whether the presence of serum and plasma anti-myelin oligodendrocyte glycoprotein (MOG) and anti-myelin basic protein (MBP) in patients presenting with a clinically isolated syndrome compatible with demyelination (CIS) predicts early conversion to multiple sclerosis (MS). Forty-seven patients with CIS (46 with optic neuritis) had anti-MOG and anti-MBP antibodies analysed at baseline, and clinical and magnetic resonance imaging assessments. There was no evidence that the MS status based on either the McDonald or Poser criteria relates to the antibody status.
引用
收藏
页码：492 / 494
页数：3
相关论文
共 10 条
  • [1] Antimyelin antibodies as a predictor of clinically definite multiple sclerosis after a first demyelinating event
    Berger, T
    Rubner, P
    Schautzer, F
    Egg, R
    Ulmer, H
    Mayringer, I
    Dilitz, E
    Deisenhammer, F
    Reindl, M
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (02) : 139 - 145
  • [2] DIFFERENTIAL ULTRASTRUCTURAL-LOCALIZATION OF MYELIN BASIC-PROTEIN, MYELIN OLIGODENDROGLIAL GLYCOPROTEIN, AND 2',3'-CYCLIC NUCLEOTIDE 3'-PHOSPHODIESTERASE IN THE CNS OF ADULT-RATS
    BRUNNER, C
    LASSMANN, H
    WAEHNELDT, TV
    MATTHIEU, JM
    LININGTON, C
    [J]. JOURNAL OF NEUROCHEMISTRY, 1989, 52 (01) : 296 - 304
  • [3] Application of the new McDonald criteria to patients with clinically isolated syndromes suggestive of multiple sclerosis
    Dalton, CM
    Brex, PA
    Miszkiel, KA
    Hickman, SJ
    MacManus, DG
    Plant, GT
    Thompson, AJ
    Miller, DH
    [J]. ANNALS OF NEUROLOGY, 2002, 52 (01) : 47 - 53
  • [4] DEROSBO NK, 1990, J NEUROCHEM, V55, P583
  • [5] Egg R, 2001, MULT SCLER J, V7, P285
  • [6] Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis
    McDonald, WI
    Compston, A
    Edan, G
    Goodkin, D
    Hartung, HP
    Lublin, FD
    McFarland, HF
    Paty, DW
    Polman, CH
    Reingold, SC
    Sandberg-Wollheim, M
    Sibley, W
    Thompson, AJ
    van den Noort, S
    Weinshenker, BY
    Wolinsky, JS
    [J]. ANNALS OF NEUROLOGY, 2001, 50 (01) : 121 - 127
  • [7] NEW DIAGNOSTIC-CRITERIA FOR MULTIPLE-SCLEROSIS - GUIDELINES FOR RESEARCH PROTOCOLS
    POSER, CM
    PATY, DW
    SCHEINBERG, L
    MCDONALD, WI
    DAVIS, FA
    EBERS, GC
    JOHNSON, KP
    SIBLEY, WA
    SILBERBERG, DH
    TOURTELLOTTE, WW
    [J]. ANNALS OF NEUROLOGY, 1983, 13 (03) : 227 - 231
  • [8] Antibodies against the myelin oligodendrocyte glycoprotein and the myelin basic protein in multiple sclerosis and other neurological diseases: a comparative study
    Reindl, M
    Linington, C
    Brehm, U
    Egg, R
    Dilitz, E
    Deisenhammer, F
    Poewe, W
    Berger, T
    [J]. BRAIN, 1999, 122 : 2047 - 2056
  • [9] New diagnostic criteria for multiple sclerosis -: Application in first demyelinating episode
    Tintoré, M
    Rovira, A
    Río, J
    Nos, C
    Grivé, E
    Sastre-Garriga, J
    Pericot, I
    Sánchez, E
    Comabella, M
    Montalban, X
    [J]. NEUROLOGY, 2003, 60 (01) : 27 - 30
  • [10] ANTIBODIES TO MYELIN-OLIGODENDROCYTE GLYCOPROTEIN IN CEREBROSPINAL-FLUID FROM PATIENTS WITH MULTIPLE-SCLEROSIS AND CONTROLS
    XIAO, BG
    LININGTON, C
    LINK, H
    [J]. JOURNAL OF NEUROIMMUNOLOGY, 1991, 31 (02) : 91 - 96
1