Inflammation and resistance to erythropoiesis-stimulating agents -: what do we know and what needs to be clarified?

被引：51
作者：
Smrzova, J
Balla, J
Bárány, P
机构：
[1] Karolinska Inst, Karolinska Univ Hosp Huddinge, Div Renal Med K56, S-14186 Huddinge, Sweden
[2] Univ Hosp Brno, Haemodialysis Ctr, Brno, Czech Republic
[3] Univ Debrecen, Div Nephrol, Debrecen, Hungary
[4] Univ Debrecen, Haemodialysis Unit, Debrecen, Hungary
来源：
NEPHROLOGY DIALYSIS TRANSPLANTATION | 2005年 / 20卷
关键词：
anaemia; darbepoetin; epoetin; hyporesponse; inflammation; resistance;
D O I：
10.1093/ndt/gfh1109
中图分类号：
R3 [基础医学]; R4 [临床医学];
学科分类号：
1001 ; 1002 ; 100602 ;
摘要：
Resistance to erythropoiesis-stimulating agents (ESA) in patients with chronic kidney disease (CKD) can be associated with evidence of enhanced systemic inflammatory responses. This review considers the inflammatory mechanisms thought to be involved in the development and aetiology of anaemia of CKD that may help our understanding and management of patients with ESA resistance. The potential role of nutritional support and of anti-inflammatory therapies in managing resistance to ESA therapy is discussed and explored.
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页码：2 / 7
页数：6
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