Overview on platelet preservation: Better controls over storage lesion

被引:75
作者
Ohto, Hitoshi [1 ]
Nollet, Kenneth E. [1 ]
机构
[1] Fukushima Med Univ, Sch Med, Dept Blood Transfus & Transplantat Immunol, Fukushima 9601295, Japan
关键词
Platelet preservation; Storage lesion; Platelet additive solution; Container; ADDITIVE SOLUTION; IN-VITRO; POLYOLEFIN CONTAINER; M-SOL; PLASMA; INTERRUPTION; ACTIVATION; MULTICENTER; MAINTENANCE; METABOLISM;
D O I
10.1016/j.transci.2011.03.008
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Platelet storage lesion (PSL), correlating with reduced in vivo recovery/survival and hemostatic capacity after transfusion, is characterized essentially by morphological and molecular evidence of platelet activation and energy consumption in the medium. Processes that limit shelf-life are multifactorial, and include both necrosis and apoptosis. PSL is greatly influenced by factors including duration of storage, temperature, ratio of platelet number to media volume, solution composition with respect to energy content and buffering capacity, and gas permeability of the container. Recent progress for slowing PSL has been made with storage media that more effectively fuel ATP production and buffer the inevitable effects of metabolism. Improved oxygen-permeability of containers also helps to maintain aerobic-dominant glycolysis. Patients stand to benefit from platelet products of higher intrinsic quality that store well until the moment of transfusion. (C) 2011 Published by Elsevier Ltd.
引用
收藏
页码:321 / 325
页数:5
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