Future Translational Applications From the Contemporary Genomics Era A Scientific Statement From the American Heart Association

被引：32

作者：

Fox, Caroline S.

Hall, Jennifer L.

Arnett, Donna K.

Ashley, Euan A.

Delles, Christian

Engler, Mary B.

Freeman, Mason W.

Johnson, Julie A.

Lanfear, David E.

Liggett, Stephen B.

Lusis, Aldons J.

Loscalzo, Joseph

MacRae, Calum A.

Musunuru, Kiran

Newby, L. Kristin

O'Donnell, Christopher J.

Rich, Stephen S.

Terzic, Andre

机构：

来源：

CIRCULATION | 2015年 / 131卷 / 19期

关键词：

AHA Scientific Statements; adrenergic beta-antagonists; DNA; genetics; genome-wide association study; HapMap Project; Human Genome Project; PCSK9; protein; mouse; polymorphism; single nucleotide; GENETIC RISK SCORE; OF-FUNCTION POLYMORPHISM; PLURIPOTENT STEM-CELLS; STAGE RENAL-DISEASE; CYP2C19; GENOTYPE; FAMILIAL HYPERCHOLESTEROLEMIA; NEOADJUVANT CHEMOTHERAPY; HOMOLOGOUS RECOMBINATION; CARDIOVASCULAR-DISEASE; MONOCLONAL-ANTIBODY;

D O I：

10.1161/CIR.0000000000000211

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The field of genetics and genomics has advanced considerably with the achievement of recent milestones encompassing the identification of many loci for cardiovascular disease and variable drug responses. Despite this achievement, a gap exists in the understanding and advancement to meaningful translation that directly affects disease prevention and clinical care. The purpose of this scientific statement is to address the gap between genetic discoveries and their practical application to cardiovascular clinical care. In brief, this scientific statement assesses the current timeline for effective translation of basic discoveries to clinical advances, highlighting past successes. Current discoveries in the area of genetics and genomics are covered next, followed by future expectations, tools, and competencies for achieving the goal of improving clinical care.

引用

页码：1715 / 1736

页数：22

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