INHIBITION OF CARBONIC ANHYDRASE I AND II WITH TOTAL ANTHOCYANINS EXTRACTED FROM SWEET CHERRY CULTIVARS

被引：5

作者：

Demir, Taki ^{[1
]}

Gunesli, Zuhal ^{[1
]}

Sonmez, Fatih ^{[1
]}

Bilen, Cigdem ^{[2
]}

Yavuz, Emre ^{[2
]}

Gencer, Nahit ^{[2
]}

机构：

[1] Sakarya Univ, Pamukova Vocat High Sch, TR-54900 Sakarya, Turkey

[2] Balikesir Univ, Dept Chem, Fac Art & Sci, TR-10145 Balikesir, Turkey

来源：

ENVIRONMENTAL ENGINEERING AND MANAGEMENT JOURNAL | 2015年 / 14卷 / 04期

关键词：

carbonic anhydrase; extraction; sweet cherry cultivars; total anthocyanins; VITRO INHIBITION; NATURAL-PRODUCTS; ERYTHROCYTE; PURIFICATION; ACID;

D O I：

10.30638/eemj.2015.104

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Total anthocyanins were extracted from six sweet cherry cultivars grown in Sakarya, Turkey. In vitro inhibition effects of the extracted total anthocyanins on purified carbonic anhydrase I and II were investigated using CO2 as a substrate. All the extracted total anthocyanins inhibited the activity of the human carbonic anhydrase (hCA) I and II enzymes. Among all the cultivars, 'Karakiraz' was found to be the most active on both hCA I (IC50 = 30.59 mu g/mL) and hCA II activity (IC50 = 44.52 mu g/mL). Additionally, all the cultivars have higher inhibitory activity on hCA I than hCA II.

引用

页码：935 / 941

页数：7

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