INHIBITION OF CARBONIC ANHYDRASE I AND II WITH TOTAL ANTHOCYANINS EXTRACTED FROM SWEET CHERRY CULTIVARS

被引：5
|
作者：
Demir, Taki [1 ]
Gunesli, Zuhal [1 ]
Sonmez, Fatih [1 ]
Bilen, Cigdem [2 ]
Yavuz, Emre [2 ]
Gencer, Nahit [2 ]
机构：
[1] Sakarya Univ, Pamukova Vocat High Sch, TR-54900 Sakarya, Turkey
[2] Balikesir Univ, Dept Chem, Fac Art & Sci, TR-10145 Balikesir, Turkey
来源：
ENVIRONMENTAL ENGINEERING AND MANAGEMENT JOURNAL | 2015年 / 14卷 / 04期
关键词：
carbonic anhydrase; extraction; sweet cherry cultivars; total anthocyanins; VITRO INHIBITION; NATURAL-PRODUCTS; ERYTHROCYTE; PURIFICATION; ACID;
D O I：
10.30638/eemj.2015.104
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Total anthocyanins were extracted from six sweet cherry cultivars grown in Sakarya, Turkey. In vitro inhibition effects of the extracted total anthocyanins on purified carbonic anhydrase I and II were investigated using CO2 as a substrate. All the extracted total anthocyanins inhibited the activity of the human carbonic anhydrase (hCA) I and II enzymes. Among all the cultivars, 'Karakiraz' was found to be the most active on both hCA I (IC50 = 30.59 mu g/mL) and hCA II activity (IC50 = 44.52 mu g/mL). Additionally, all the cultivars have higher inhibitory activity on hCA I than hCA II.
引用
收藏
页码：935 / 941
页数：7
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