Protease-activated receptors in cancer: A systematic review

被引：43

作者：

Han, Na ^{[1
,2
]}

Jin, Ketao ^{[3
,4
]}

He, Kuifeng ^{[3
]}

Cao, Jiang ^{[1
,2
,5
]}

Teng, Lisong ^{[3
]}

机构：

[1] Zhejiang Univ, Sir Run Run Shaw Inst Clin Med, Hangzhou 310016, Zhejiang, Peoples R China

[2] Key Lab Biotherapy Zhejiang Prov, Hangzhou 310016, Zhejiang, Peoples R China

[3] Zhejiang Univ, Dept Surg Oncol, Affiliated Hosp 1, Coll Med, Hangzhou 310003, Zhejiang, Peoples R China

[4] Wenzhou Med Coll, Zhuji Hosp, Dept Surg, Zhuji 311800, Zhejiang, Peoples R China

[5] Zhejiang Univ, Coll Med, Affiliated Hosp 2, Clin Res Ctr, Hangzhou 310003, Zhejiang, Peoples R China

来源：

ONCOLOGY LETTERS | 2011年 / 2卷 / 04期

基金：

中国国家自然科学基金;

关键词：

angiogenesis; cancer; protease-activated receptors; tumorigenesis; MOLECULAR-WEIGHT HEPARIN; ENDOTHELIAL GROWTH-FACTOR; THROMBIN-INDUCED ANGIOGENESIS; PEPDUCIN-BASED INTERVENTION; HUMAN PLATELET ACTIVATION; TUMOR-SUPPRESSOR PROTEIN; TISSUE FACTOR; IN-VITRO; CELL-PROLIFERATION; ANTIANGIOGENIC AGENTS;

D O I：

10.3892/ol.2011.291

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The traditional view of the role of proteases in tumor growth, progression and metastasis has significantly changed. Apart from their contribution to cancer progression, it is evident that a subclass of proteases, such as thrombin, serves as signal molecules controlling cell functions through the protease-activated receptors (PARs). Among the four types of PAR (PAR 1-4; cloned and named in order of their discovery), PAR1, PAR3 and PAR4 are activated by thrombin, unlike PAR2, which is activated by trypsin-like serine proteases. Thrombin has been proven to be a significant factor in both the behavior of cancer in its involvement in hemostasis and blood coagulation. Thrombin is a key supporter of various cellular effects relevant to tumor growth and metastasis, as well as a potent activator of angiogenesis, which is essential for the growth and development of all solid tumor types. This review presents an overview of the role of PAR-mediated thrombin in angiogenesis and cancer, focusing on the ability of PAR1- and PAR4-mediated thrombin to affect tumorigenesis and angiogenesis.

引用

页码：599 / 608

页数：10

共 157 条

[61] Integrin affinity modulation [J].