Protease-activated receptors in cancer: A systematic review

被引：42
作者：
Han, Na [1 ,2 ]
Jin, Ketao [3 ,4 ]
He, Kuifeng [3 ]
Cao, Jiang [1 ,2 ,5 ]
Teng, Lisong [3 ]
机构：
[1] Zhejiang Univ, Sir Run Run Shaw Inst Clin Med, Hangzhou 310016, Zhejiang, Peoples R China
[2] Key Lab Biotherapy Zhejiang Prov, Hangzhou 310016, Zhejiang, Peoples R China
[3] Zhejiang Univ, Dept Surg Oncol, Affiliated Hosp 1, Coll Med, Hangzhou 310003, Zhejiang, Peoples R China
[4] Wenzhou Med Coll, Zhuji Hosp, Dept Surg, Zhuji 311800, Zhejiang, Peoples R China
[5] Zhejiang Univ, Coll Med, Affiliated Hosp 2, Clin Res Ctr, Hangzhou 310003, Zhejiang, Peoples R China
来源：
ONCOLOGY LETTERS | 2011年 / 2卷 / 04期
基金：
中国国家自然科学基金;
关键词：
angiogenesis; cancer; protease-activated receptors; tumorigenesis; MOLECULAR-WEIGHT HEPARIN; ENDOTHELIAL GROWTH-FACTOR; THROMBIN-INDUCED ANGIOGENESIS; PEPDUCIN-BASED INTERVENTION; HUMAN PLATELET ACTIVATION; TUMOR-SUPPRESSOR PROTEIN; TISSUE FACTOR; IN-VITRO; CELL-PROLIFERATION; ANTIANGIOGENIC AGENTS;
D O I：
10.3892/ol.2011.291
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The traditional view of the role of proteases in tumor growth, progression and metastasis has significantly changed. Apart from their contribution to cancer progression, it is evident that a subclass of proteases, such as thrombin, serves as signal molecules controlling cell functions through the protease-activated receptors (PARs). Among the four types of PAR (PAR 1-4; cloned and named in order of their discovery), PAR1, PAR3 and PAR4 are activated by thrombin, unlike PAR2, which is activated by trypsin-like serine proteases. Thrombin has been proven to be a significant factor in both the behavior of cancer in its involvement in hemostasis and blood coagulation. Thrombin is a key supporter of various cellular effects relevant to tumor growth and metastasis, as well as a potent activator of angiogenesis, which is essential for the growth and development of all solid tumor types. This review presents an overview of the role of PAR-mediated thrombin in angiogenesis and cancer, focusing on the ability of PAR1- and PAR4-mediated thrombin to affect tumorigenesis and angiogenesis.
引用
收藏
页码：599 / 608
页数：10
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