Molecular imaging and depth profiling by mass spectrometry-SIMS, MALDI or DESI?

被引：184

作者：

Vickerman, John C. ^{[1
]}

机构：

[1] Univ Manchester, Manchester Interdisciplinary Bioctr, Sch Chem Engn & Analyt Sci, Res Grp, Manchester, Lancs, England

来源：

ANALYST | 2011年 / 136卷 / 11期

基金：

英国工程与自然科学研究理事会;

关键词：

ASSISTED-LASER-DESORPTION/IONIZATION; DESORPTION ELECTROSPRAY-IONIZATION; FAST-ATOM-BOMBARDMENT; PRIMARY ION-BEAM; TOF-SIMS; TISSUE-SECTIONS; DYNAMICS MODEL; RAPID ANALYSIS; THIN-FILMS; CLUSTER;

D O I：

10.1039/c1an00008j

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The possibility of exploiting the analytical power of mass spectrometry to image the chemistry of biological and similarly complex materials without the use of tags and with good spatial resolution is seductive. The status, strengths, weaknesses and complementarity of the three main techniques are briefly reviewed and assessed.

引用

页码：2199 / 2217

页数：19

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