Ca2+ receptor from brain to gut:: Common stimulus, diverse actions

被引：29
作者：
Chattopadhyay, N
Yamaguchi, T
Brown, EM
机构：
[1] Brigham & Womens Hosp, Dept Med, Div Endocrine Hypertens, Boston, MA 02115 USA
[2] Harvard Med Sch, Boston, MA 02115 USA
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1998年 / 9卷 / 09期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/S1043-2760(98)00090-3
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
An extracellular Ca2--sensing receptor (CaR) plays central roles in Ca2+ homeostasis by regulating parathyroid hormone (PTH) secretion and venal Ca2+ handling. The CaR is also expressed in intestine and bone, where its functions in mineral metabolism are not yet well defined. The receptor is also present in various types of cells seemingly uninvolved in systemic mineral ion homeostasis (such as neuronal and glial cells in the brain and various epithelial cells), where ifs actions are poorly understood but might involve the regulation of local ionic homeostasis and/or diverse cellular processes, such as cellular differentiation and proliferation.
引用
收藏
页码：354 / 359
页数：6
相关论文
共 54 条
[1]   Specific coupling of a cation-sensing receptor to G protein alpha-subunits in MDCK cells [J].
Arthur, JM ;
Collinsworth, GP ;
Gettys, TW ;
Quarles, LD ;
Raymond, JR .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 1997, 273 (01) :F129-F135
[2]   Changes in calcium responsiveness and handling during keratinocyte differentiation - Potential role of the calcium receptor [J].
Bikle, DD ;
Ratnam, A ;
Mauro, T ;
Harris, J ;
Pillai, S .
JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (04) :1085-1093
[3]  
Brown E. M., 1997, REGULATORY PEPTIDE L, VVII, P43
[4]   CLONING AND CHARACTERIZATION OF AN EXTRACELLULAR CA2+-SENSING RECEPTOR FROM BOVINE PARATHYROID [J].
BROWN, EM ;
GAMBA, G ;
RICCARDI, D ;
LOMBARDI, M ;
BUTTERS, R ;
KIFOR, O ;
SUN, A ;
HEDIGER, MA ;
LYTTON, J ;
HEBERT, SC .
NATURE, 1993, 366 (6455) :575-580
[5]   Calcium-receptor-regulated parathyroid and renal function [J].
Brown, EM ;
Hebert, SC .
BONE, 1997, 20 (04) :303-309
[6]   EXTRACELLULAR CA2+ SENSING, REGULATION OF PARATHYROID CELL-FUNCTION, AND ROLE OF CA2+ AND OTHER IONS AS EXTRACELLULAR (1ST) MESSENGERS [J].
BROWN, EM .
PHYSIOLOGICAL REVIEWS, 1991, 71 (02) :371-411
[7]   Coupling of calcium receptors to inositol phosphate and cyclic AMP generation in mammalian cells and Xenopus laevis oocytes and immunodetection of receptor protein by region-specific antipeptide antisera [J].
Chang, WH ;
Pratt, S ;
Chen, TH ;
Nemeth, E ;
Huang, ZM ;
Shoback, D .
JOURNAL OF BONE AND MINERAL RESEARCH, 1998, 13 (04) :570-580
[8]   Identification and localization of extracellular Ca2+-sensing receptor in rat intestine [J].
Chattopadhyay, N ;
Cheng, I ;
Rogers, K ;
Riccardi, D ;
Hall, A ;
Diaz, R ;
Hebert, SC ;
Soybel, DI ;
Brown, EM .
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 1998, 274 (01) :G122-G130
[9]   Expression of extracellular calcium-sensing receptor by human lens epithelial cells [J].
Chattopadhyay, N ;
Ye, CP ;
Singh, DP ;
Kifor, O ;
Vassilev, PM ;
Shinohara, T ;
Chylack, LT ;
Brown, EM .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 233 (03) :801-805
[10]   The calcium-sensing receptor: A window into the physiology and pathophysiology of mineral ion metabolism [J].
Chattopadhyay, N ;
Mithal, A ;
Brown, EM .
ENDOCRINE REVIEWS, 1996, 17 (04) :289-307
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