Synthesis of 2′-O-α-D-ribofuranosyladenosine, monomeric unit of poly(ADP-ribose)

被引：24
|
作者：
Mikhailov, Sergey N. [1 ]
Kulikova, Irina V. [1 ]
Nauwelaerts, Koen [2 ]
Herdewijn, Piet [2 ]
机构：
[1] Russian Acad Sci, VA Engelhardt Mol Biol Inst, Moscow 119991, Russia
[2] Katholieke Univ Leuven, Med Chem Lab, Rega Inst Med Res, B-3000 Louvain, Belgium
来源：
TETRAHEDRON | 2008年 / 64卷 / 12期
基金：
俄罗斯基础研究基金会;
关键词：
poly(ADP-ribose); monomeric unit; stereoselective synthesis;
D O I：
10.1016/j.tet.2008.01.028
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first chemical synthesis of 2'-O-alpha-D-ribofuranosyladenosine, monomeric unit of poly(ADP-ribose), has been achieved starting from 3',5'-O-bis protected 9-(2-O-alpha-D-arabinofuranosyl-beta-D-ribofuranosyl)-adenine. Configurational inversion of 2'-hydroxyl group of arabinose moiety was performed by oxidation-reduction sequence. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2871 / 2876
页数：6
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