Pair distribution functions of amorphous organic thin films from synchrotron X-ray scattering in transmission mode

被引：10
作者：
Shi, Chenyang [1 ]
Teerakapibal, Rattavut [2 ]
Yu, Lian [2 ]
Zhang, Geoff G. Z. [1 ]
机构：
[1] AbbVie Inc, Res & Dev, Drug Prod Dev, 1 North Waukegan Rd, N Chicago, IL 60064 USA
[2] Univ Wisconsin, Sch Pharm, Madison, WI 53705 USA
来源：
IUCRJ | 2017年 / 4卷
基金：
美国国家科学基金会;
关键词：
pair distribution functions; amorphous organic thin films; transmission X-ray scattering; indomethacin; INDOMETHACIN; DIFFRACTION;
D O I：
10.1107/S2052252517009344
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Using high-brilliance high-energy synchrotron X-ray radiation, for the first time the total scattering of a thin organic glass film deposited on a strongly scattering inorganic substrate has been measured in transmission mode. The organic thin film was composed of the weakly scattering pharmaceutical substance indomethacin in the amorphous state. The film was 130 mm thick atop a borosilicate glass substrate of equal thickness. The atomic pair distribution function derived from the thin-film measurement is in excellent agreement with that from bulk measurements. This ability to measure the total scattering of amorphous organic thin films in transmission will enable accurate in situ structural studies for a wide range of materials.
引用
收藏
页码：555 / 559
页数：5
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