A highly efficient regioselective one-pot synthesis of 2,3,6-trisubstituted pyridines and 2,7,7-trisubstituted tetrahydroquinolin-5-ones using K5CoW12O40•3H2O as a heterogeneous recyclable catalyst

被引：62

作者：

Kantevari, Srinivas ^{[1
]}

Chary, Mahankhali Venu ^{[1
]}

Vuppalapati, Srinivasu V. N. ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Organ Chem Div 2, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON | 2007年 / 63卷 / 52期

关键词：

D O I：

10.1016/j.tet.2007.10.014

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A systematic investigation into the regioselective one-pot, three-component condensation of enaminones la-g, beta-dicarbonyl compounds 2a-c, and ammonium acetate in the presence of a catalytic amount of K5CoW12O40 center dot 3H(2)O (0.01 equiv or 1.0 mol %) under solvent free conditions, as well as in refluxing isopropanol, has been reported. The reaction was highly efficient to produce 2,3,6-trisubstituted pyridines 3a-g, 4a-g, and novel 2,7,7-trisubstituted-5,6,7,8-tetrahydroquinoline-5-ones 5a-g in excellent yields. The present procedure offers advantages of short reaction time, simple work-up, and the catalyst exhibited remarkable reusable activity. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：13024 / 13031

页数：8

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