A Multicenter Study of Viral Aetiology of Community-Acquired Pneumonia in Hospitalized Children in Chinese Mainland

被引:18
|
作者
Zhu, Yun [1 ]
Xu, Baoping [2 ]
Li, Changchong [3 ]
Chen, Zhimin [4 ]
Cao, Ling [5 ]
Fu, Zhou [6 ]
Shang, Yunxiao [7 ]
Chen, Aihuan [8 ]
Deng, Li [9 ]
Bao, Yixiao [10 ]
Sun, Yun [11 ]
Ning, Limin [12 ]
Yu, Shuilian [13 ]
Gu, Fang [14 ]
Liu, Chunyan [1 ]
Yin, Ju [2 ]
Shen, Adong [15 ]
Xie, Zhengde [1 ]
Shen, Kunling [16 ]
机构
[1] Capital Med Univ, Beijing Childrens Hosp,Key Lab Major Dis Children, Chinese Acad Med Sci,Beijing Key Lab Pediat Resp, Lab Infect & Virol,Beijing Pediat Res Inst,Res Un, Beijing 100045, Peoples R China
[2] Capital Med Univ, Beijing Childrens Hosp, Dept Resp Dis 1, Natl Clin Res Ctr Resp Dis,Natl Ctr Childrens Hlt, Beijing 100045, Peoples R China
[3] Wenzhou Med Univ, Affiliated Hosp & Yuying Childrens Hosp 2, Wenzhou 325027, Peoples R China
[4] Childrens Hosp Zhejiang Univ Sch Med, Hangzhou 310005, Zhejiang, Peoples R China
[5] Childrens Hosp Capital Inst Pediat, Beijing 100020, Peoples R China
[6] Childrens Hosp Chongqing Med Univ, Chongqing 400015, Peoples R China
[7] Shengjing Hosp China Med Univ, Shenyang 110004, Liaoning, Peoples R China
[8] First Affiliated Hosp Guangzhou Med Univ, Guangzhou 510120, Guangdong, Peoples R China
[9] Guangzhou Women & Childrens Med Ctr, Guangzhou 510623, Guangdong, Peoples R China
[10] Xinhua Hosp Affiliated Shanghai Jiao Tong Univ Sc, Shanghai 200092, Peoples R China
[11] Yinchuan Women & Children Healthcare Hosp, Yinchuan 750000, Ningxia, Peoples R China
[12] Childrens Hosp Changchun, Changchun 130000, Jilin, Peoples R China
[13] 2nd Affiliated Hosp Harbin Med Univ, Harbin 150086, Heilongjiang, Peoples R China
[14] Baoding Childrens Hosp, Baoding 071051, Peoples R China
[15] Capital Med Univ, Beijing Childrens Hosp,Natl Clinical Res Ctr Resp, Beijing Key Lab Pediat Resp Infect Dis,Minist Edu, Lab Resp Dis,Beijing Pediat Res Inst,Key Lab Majo, Beijing 100045, Peoples R China
[16] Capital Med Univ, Beijing Childrens Hosp, Natl Clin Res Ctr Resp Dis, Natl Ctr Childrens Hlth, Beijing 100045, Peoples R China
关键词
Children; Community-acquired pneumonia; Multicenter study; Viral aetiology; Multiplex PCR assay; HUMAN METAPNEUMOVIRUS INFECTION; ACUTE RESPIRATORY-INFECTION; HUMAN BOCAVIRUS; EPIDEMIOLOGY; VIRUSES; PICORNAVIRUSES; ASSOCIATION; FEATURES; INFANTS; ASSAY;
D O I
10.1007/s12250-021-00437-0
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Community-acquired pneumonia (CAP) is one of the leading causes of morbidity and mortality in children worldwide. In this study, we aimed to describe the aetiology of viral infection of pediatric CAP in Chinese mainland. During November 2014 to June 2016, the prospective study was conducted in 13 hospitals. The hospitalized children under 18 years old who met the criteria for CAP were enrolled. The throat swabs or nasopharyngeal aspirates (NPAs) were collected which were then screened 18 respiratory viruses using multiplex PCR assay. Viral pathogens were present in 56.6% (1539/2721) of the enrolled cases, with the detection rate of single virus in 39.8% of the cases and multiple viruses in 16.8% of the cases. The most frequently detected virus was respiratory syncytial virus (RSV) (15.2%, 414/2721). The highest detection rate of virus was in < 6-month-age group (70.7%, 292/413). RSV, human metapneumovirus (HMPV), human parainfluenza viruses (HPIVs) and influenza B virus (Flu B) showed the similar prevalence patterns both in north and south China, but HPIVs, Flu A, human bocavirus (HBoV), human adenovirus (HAdV) and human coronaviruses (HCoVs) showed the distinct circulating patterns in north and south China. Human enterovirus/human rhinovirus (HEV/HRV) (27.6%, 27/98), HBoV (18.4%, 18/98), RSV (16.3%, 16/98) and HMPV (14.3%, 14/98) were the most commonly detected viruses in severe pneumonia cases with single virus infection. In conclusion, viral pathogens are frequently detected in pediatric CAP cases and may therefore play a vital role in the aetiology of CAP. RSV was the most important virus in hospitalized children with CAP in Chinese mainland.
引用
收藏
页码:1543 / 1553
页数:11
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