The Advances of Neutrophil-Derived Effective Drug Delivery Systems: A Key Review of Managing Tumors and Inflammation

被引：47
作者：
Wang, Huaiji [1 ]
Zang, Jie [2 ]
Zhao, Zihan [3 ]
Zhang, Qin [1 ]
Chen, Shunjie [1 ]
机构：
[1] Tongji Univ, Shanghai Peoples Hosp 4, Sch Med, Dept Nephrol, Shanghai, Peoples R China
[2] Tongji Univ, Sch Med, Inst Biomed Engn & Nano Sci, Shanghai, Peoples R China
[3] Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Dermatol, Shanghai, Peoples R China
来源：
INTERNATIONAL JOURNAL OF NANOMEDICINE | 2021年 / 16卷
关键词：
neutrophil-derived delivery; tumors and inflammation; targeting; circulation; biostability; CELL-MEMBRANE; NANOPARTICLES; NANOVESICLES; NANOCARRIERS; STRATEGIES; LIPOSOMES; BARRIERS;
D O I：
10.2147/IJN.S328705
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
The chimeric trait of recruitment by inflammatory signals endows neutrophils with the functionality of migrating to inflamed tissues, which can be utilized to tailor novel drug delivery systems. In this review, we introduce a mechanism of neutrophil-derived drug delivery systems recruited into inflamed sites and provide insight into tumors and inflammation therapy. In particular, the advantages of neutrophils-their endogenous-derived neutrophil membrane, exosomes as drug carriers for augmented targeting, prolonged circulation, and improved biostability-were concluded. Subsequently, the latest application in the treatment of tumors and inflammation was elaborated upon, followed by a discussion of the future prospects to neutrophil-derived delivery systems. This promising system will provide new therapeutic avenues for the treatment of inflammation and tumors.
引用
收藏
页码：7663 / 7681
页数：19
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