Microwave-assisted novel synthesis of amino-thieno[3,2-b]pyridines under solvent-free conditions

被引：12

作者：

Su, Weike ^{[1
]}

Guo, Shaozheng ^{[1
]}

Hong, Zhi ^{[1
,2
]}

Chen, Ren'er ^{[2
]}

机构：

[1] Zhejiang Univ Technol, Key Lab Pharmaceut Engn, Minist Educ, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China

[2] Taizhou Univ, Sch Pharmaceut & Chem Engn, Linhai 317000, Peoples R China

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 43期

基金：

浙江省自然科学基金; 中国国家自然科学基金;

关键词：

Microwave-assisted; Solvent-free; Ytterbium triflate; Amino-thieno[2,3-b]pyridine derivatives; Combes reaction; TYROSINE KINASE INHIBITORS; GROWTH-FACTOR RECEPTOR; ATP-BINDING-SITE; YTTERBIUM(III) TRIFLATE; ORGANIC-SYNTHESIS; DERIVATIVES; IRRADIATION; PYRIMIDINE; ALCOHOLS; SERIES;

D O I：

10.1016/j.tetlet.2010.08.075

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the presence of a catalytic amount of ytterbium(III) triflate and under microwave irradiation, mixtures of 2-amino-3-thiophenecarbonitriles, ketones, and silica gel afforded smoothly the corresponding aminothieno[2,3-b]pyridine derivatives in one step. A wide variety of ketones were tested under these conditions. The reactions proceeded rapidly and afforded the desired products in good to excellent yields. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：5718 / 5720

页数：3

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