Targeting Metalloenzymes for Therapeutic Intervention

被引：214

作者：

Chen, Allie Y. ^{[1
]}

Adamek, Rebecca N. ^{[1
]}

Dick, Benjamin L. ^{[1
]}

Credille, Cy V. ^{[1
]}

Morrison, Christine N. ^{[1
]}

Cohen, Seth M. ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

来源：

CHEMICAL REVIEWS | 2019年 / 119卷 / 02期

关键词：

CATECHOL-O-METHYLTRANSFERASE; ANGIOTENSIN-CONVERTING ENZYME; HIV-1; REVERSE-TRANSCRIPTASE; D-ALANINE LIGASE; ALANYL-D-ALANINE; ANTHRAX LETHAL FACTOR; 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE; HISTONE DEACETYLASE INHIBITORS; KETOL-ACID REDUCTOISOMERASE; SMALL-MOLECULE INHIBITORS;

D O I：

10.1021/acs.chemrev.8b00201

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Metalloenzymes are central to a wide range of essential biological activities, including nucleic acid modification, protein degradation, and many others. The role of metalloenzymes in these processes also makes them central for the progression of many diseases and, as such, makes metalloenzymes attractive targets for therapeutic intervention. Increasing awareness of the role metalloenzymes play in disease and their importance as a class of targets has amplified interest in the development of new strategies to develop inhibitors and ultimately useful drugs. In this Review, we provide a broad overview of several drug discovery efforts focused on metalloenzymes and attempt to map out the current landscape of high-value metalloenzyme targets.

引用

页码：1323 / 1455

页数：133

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