A coumarin-based turn-on chemosensor for selective detection of Zn(II) and application in live cell imaging

被引：23
作者：
Shang Yanfang [1 ]
Wang Hualai [1 ]
Bai Hui [2 ]
机构：
[1] Nantong Univ, Sch Chem & Chem Engn, Nantong 226019, Peoples R China
[2] Taiyuan Univ Technol, Minist Educ & Shanxi Prov, Key Lab Coal Sci & Technol, Taiyuan 030024, Peoples R China
来源：
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2020年 / 228卷
关键词：
Cell imaging; Coumarin-based; DFT study; Zn2+; Recognition mechanism; PHOTOPHYSICAL PROPERTIES; FLUORESCENT CHEMOSENSOR; SCHIFF-BASE; ZN2+; ZINC; SENSOR; PROBE; ACCUMULATION; AGGREGATION; SENSITIVITY;
D O I：
10.1016/j.saa.2019.117746
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
A 2-oxo-2H-chromene-3-carbohydrazide (CHB) was synthesized by the reaction of salicylaldehyde with diethyl malonate and hydrazine hydrate. The recognition behaviors of CHB to Zn2+ were investigated and the results showed that CHB exhibits well selectivity and sensitivity to Zn2+ with fast response in PBS (pH = 7.24, 60% DMF), the co-existed cations and anions could not interfere the recognition between CHB and Zn2+. Besides, the detection limit of CHB for Zn2+ was calculated to be 0.95 mu M. Furthermore, DFT, EI-MS data and Job's plot were applied for determining the sensing mechanism of CHB with Zn2+ and the results showed that a type of 2:1 complex was formed between CHB and Zn2+ with the binding constant was 1.32 x 10(4) M-2. At last, probe CHB was successfully applied for the imaging of Zn2+ in living cells. (C) 2019 Elsevier B.V. All rights reserved.
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页数：8
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