Resolution of pentafluorophenyl esters using oxazolidin-2-ones

被引：0

作者：

Al Shaye, Najla ^{[1
]}

Eames, Jason ^{[1
]}

机构：

[1] Univ Hull, Dept Chem, Kingston Upon Hull HU6 7RX, Yorks, England

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 45期

关键词：

PARALLEL KINETIC RESOLUTION; ENANTIOMERIC EVANS OXAZOLIDINONES; ACIDS; COMBINATION; AUXILIARY; ALKYLATION; PROFENS;

D O I：

10.1016/j.tetlet.2010.08.109

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of structurally related racemic pentafluorophenyl active esters were resolved using an equimolar amount of (S)-4-phenyloxazolidin-2-one. The levels of diastereocontrol were found to be excellent (80-96% de) at similar to 40% conversion. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：5892 / 5895

页数：4

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