Inhibitors selective for HDAC6 in enzymes and cells

被引：33

作者：

Gupta, Praveer K. ^{[1
]}

Reid, Robert C. ^{[1
]}

Liu, Ligong ^{[1
]}

Lucke, Andrew J. ^{[1
]}

Broomfield, Steve A. ^{[1
]}

Andrews, Melanie R. ^{[1
]}

Sweet, Matthew J. ^{[1
]}

Fairlie, David P. ^{[1
]}

机构：

[1] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 23期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

HDAC6; Enzyme inhibitor; Anti-inflammatory; Inflammation; HISTONE DEACETYLASE INHIBITORS; PROTEIN SIR2; FAMILY; TUBULIN; CLONING; DESIGN; YEAST; MICE;

D O I：

10.1016/j.bmcl.2010.09.100

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Histone deacetylase inhibitors with anticancer or anti-inflammatory activity bind to Class I or Class I and II HDAC enzymes. Here we compare selectivity of inhibitors of a Class II HDAC enzyme (HDAC6) and find one that retains high selectivity in macrophages. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：7067 / 7070

页数：4

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