Tissue-specific ablation of the GLUT4 glucose transporter or the insulin receptor challenges assumptions about insulin action and glucose homeostasis

被引：178

作者：

Minokoshi, Y

Kahn, CR

Kahn, BB

机构：

[1] Beth Israel Deaconess Med Ctr, Div Endocrinol Diabet & Metab, Boston, MA 02215 USA

[2] Harvard Univ, Sch Med, Dept Med, Boston, MA 02215 USA

[3] Harvard Univ, Sch Med, Joslin Diabet Ctr, Boston, MA 02215 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2003年 / 278卷 / 36期

关键词：

D O I：

10.1074/jbc.R300019200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：33609 / 33612

页数：4

共 37 条

[1] Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver [J].

Abel, ED ;

Peroni, O ;

Kim, JK ;

Kim, YB ;

Boss, O ;

Hadro, E ;

Minnemann, T ;

Shulman, GI ;

Kahn, BB .

NATURE, 2001, 409 (6821) :729-733

[2] Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart [J].

Abel, ED ;

Kaulbach, HC ;

Tian, R ;

Hopkins, JCA ;

Duffy, J ;

Doetschman, T ;

Minnemann, T ;

Boers, ME ;

Hadro, E ;

Oberste-Berghaus, C ;

Quist, W ;

Lowell, BB ;

Ingwall, JS ;

Kahn, BB .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (12) :1703-1714

[3] Early neonatal death in mice homozygous for a null allele of the insulin receptor gene [J].

Accili, D ;

Drago, J ;

Lee, EJ ;

Johnson, MD ;

Cool, MH ;

Salvatore, P ;

Asico, LD ;

Jose, PA ;

Taylor, SI ;

Westphal, H .

NATURE GENETICS, 1996, 12 (01) :106-109

[4] Type 2 diabetes impairs splanchnic uptake of glucose but does not alter intestinal glucose absorption during enteral glucose feeding - Additional evidence for a defect in hepatic glucokinase activity [J].

Basu, A ;

Basu, R ;

Shah, P ;

Vella, A ;

Johnson, CM ;

Jensen, M ;

Nair, KS ;

Schwenk, WF ;

Rizza, RA .

DIABETES, 2001, 50 (06) :1351-1362

[5] Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression [J].

Belke, DD ;

Betuing, S ;

Tuttle, MJ ;

Graveleau, C ;

Young, ME ;

Pham, M ;

Zhang, DF ;

Cooksey, RC ;

McClain, DA ;

Litwin, SE ;

Taegtmeyer, H ;

Severson, D ;

Kahn, CR ;

Abel, ED .

JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (05) :629-639

[6] Extended longevity in mice lacking the insulin receptor in adipose tissue [J].

Blüher, M ;

Kahn, BB ;

Kahn, CR .

SCIENCE, 2003, 299 (5606) :572-574

[7] Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance [J].

Blüher, M ;

Michael, MD ;

Peroni, OD ;

Ueki, K ;

Carter, N ;

Kahn, BB ;

Kahn, CR .

DEVELOPMENTAL CELL, 2002, 3 (01) :25-38

[8] A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance [J].

Bruning, JC ;

Michael, MD ;

Winnay, JN ;

Hayashi, T ;

Horsch, D ;

Accili, D ;

Goodyear, LJ ;

Kahn, CR .

MOLECULAR CELL, 1998, 2 (05) :559-569

[9] Regulated transport of the glucose transporter glut4 [J].

Bryant, NJ ;

Govers, R ;

James, DE .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (04) :267-277

[10] Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes [J].

Cline, GW ;

Petersen, KF ;

Krssak, M ;

Shen, J ;

Hundal, RS ;

Trajanoski, Z ;

Inzucchi, S ;

Dresner, A ;

Rothman, DL ;

Shulman, GI .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (04) :240-246

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