Tissue-specific ablation of the GLUT4 glucose transporter or the insulin receptor challenges assumptions about insulin action and glucose homeostasis

被引：177
作者：
Minokoshi, Y
Kahn, CR
Kahn, BB
机构：
[1] Beth Israel Deaconess Med Ctr, Div Endocrinol Diabet & Metab, Boston, MA 02215 USA
[2] Harvard Univ, Sch Med, Dept Med, Boston, MA 02215 USA
[3] Harvard Univ, Sch Med, Joslin Diabet Ctr, Boston, MA 02215 USA
来源：
JOURNAL OF BIOLOGICAL CHEMISTRY | 2003年 / 278卷 / 36期
关键词：
D O I：
10.1074/jbc.R300019200
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：33609 / 33612
页数：4
相关论文
共 37 条
  • [1] Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
    Abel, ED
    Peroni, O
    Kim, JK
    Kim, YB
    Boss, O
    Hadro, E
    Minnemann, T
    Shulman, GI
    Kahn, BB
    [J]. NATURE, 2001, 409 (6821) : 729 - 733
  • [2] Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart
    Abel, ED
    Kaulbach, HC
    Tian, R
    Hopkins, JCA
    Duffy, J
    Doetschman, T
    Minnemann, T
    Boers, ME
    Hadro, E
    Oberste-Berghaus, C
    Quist, W
    Lowell, BB
    Ingwall, JS
    Kahn, BB
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (12) : 1703 - 1714
  • [3] Early neonatal death in mice homozygous for a null allele of the insulin receptor gene
    Accili, D
    Drago, J
    Lee, EJ
    Johnson, MD
    Cool, MH
    Salvatore, P
    Asico, LD
    Jose, PA
    Taylor, SI
    Westphal, H
    [J]. NATURE GENETICS, 1996, 12 (01) : 106 - 109
  • [4] Type 2 diabetes impairs splanchnic uptake of glucose but does not alter intestinal glucose absorption during enteral glucose feeding - Additional evidence for a defect in hepatic glucokinase activity
    Basu, A
    Basu, R
    Shah, P
    Vella, A
    Johnson, CM
    Jensen, M
    Nair, KS
    Schwenk, WF
    Rizza, RA
    [J]. DIABETES, 2001, 50 (06) : 1351 - 1362
  • [5] Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression
    Belke, DD
    Betuing, S
    Tuttle, MJ
    Graveleau, C
    Young, ME
    Pham, M
    Zhang, DF
    Cooksey, RC
    McClain, DA
    Litwin, SE
    Taegtmeyer, H
    Severson, D
    Kahn, CR
    Abel, ED
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (05) : 629 - 639
  • [6] Extended longevity in mice lacking the insulin receptor in adipose tissue
    Blüher, M
    Kahn, BB
    Kahn, CR
    [J]. SCIENCE, 2003, 299 (5606) : 572 - 574
  • [7] Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance
    Blüher, M
    Michael, MD
    Peroni, OD
    Ueki, K
    Carter, N
    Kahn, BB
    Kahn, CR
    [J]. DEVELOPMENTAL CELL, 2002, 3 (01) : 25 - 38
  • [8] A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance
    Bruning, JC
    Michael, MD
    Winnay, JN
    Hayashi, T
    Horsch, D
    Accili, D
    Goodyear, LJ
    Kahn, CR
    [J]. MOLECULAR CELL, 1998, 2 (05) : 559 - 569
  • [9] Regulated transport of the glucose transporter glut4
    Bryant, NJ
    Govers, R
    James, DE
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (04) : 267 - 277
  • [10] Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes
    Cline, GW
    Petersen, KF
    Krssak, M
    Shen, J
    Hundal, RS
    Trajanoski, Z
    Inzucchi, S
    Dresner, A
    Rothman, DL
    Shulman, GI
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (04) : 240 - 246
1234