Epstein-Barr virus-host cell interactions: an epigenetic dialog?

被引:25
作者
Niller, Hans H. [1 ]
Szenthe, Kalman [2 ]
Minarovits, Janos [3 ]
机构
[1] Univ Regensburg, Inst Med Microbiol & Hyg, D-93053 Regensburg, Germany
[2] RT Europe Nonprofit Res Ltd, Mosonmagyarovar, Hungary
[3] Univ Szeged, Fac Dent, Dept Oral Biol & Expt Dent Res, Szeged, Hungary
来源
FRONTIERS IN GENETICS | 2014年 / 5卷
关键词
PROTEIN-COUPLED RECEPTOR; DNA METHYLATION; NASOPHARYNGEAL CARCINOMA; THYMIDYLATE SYNTHASE; HERPESVIRUS-SAIMIRI; BURKITTS-LYMPHOMA; GASTRIC-CARCINOMA; GENE-EXPRESSION; BINDING-SITE; IN-VIVO;
D O I
10.3389/fgene.2014.00367
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Here, we wish to highlight the genetic exchange and epigenetic interactions between Epstein-Barr virus (EBV) and its host. EBV is associated with diverse lymphoid and epithelial malignancies. Their molecular pathogenesis is accompanied by epigenetic alterations which are distinct for each of them. While lymphoblastoid cell lines derived from B cells transformed by EBV in vitro are characterized by a massive demethylation and euchromatinization of the viral and cellular genomes, the primarily malignant lymphoid tumor Burkitts lymphoma and the epithelial tumors nasopharyngeal carcinoma and EBV-associated gastric carcinoma are characterized by hypermethylation of a multitude of cellular tumor suppressor gene loci and of the viral genomes. In some cases, the viral latency and oncoproteins including the latent membrane proteins LMP1 and LMP2A and several nuclear antigens affect the level of cellular DNA methyltransferases or interact with the histone modifying machinery. Specific molecular mechanisms of the epigenetic dialog between virus and host cell remain to be elucidated.
引用
收藏
页数:6
相关论文
共 67 条
  • [21] THE A+T-RICH GENOME OF HERPESVIRUS-SAIMIRI CONTAINS A HIGHLY CONSERVED GENE FOR THYMIDYLATE SYNTHASE
    HONESS, RW
    BODEMER, W
    CAMERON, KR
    NILLER, HH
    FLECKENSTEIN, B
    RANDALL, RE
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (11) : 3604 - 3608
  • [22] EXPRESSION OF INTERLEUKIN-10 ACTIVITY BY EPSTEIN-BARR-VIRUS PROTEIN BCRF1
    HSU, DH
    MALEFYT, RD
    FIORENTINO, DF
    DANG, MN
    VIEIRA, P
    DEVRIES, J
    SPITS, H
    MOSMANN, TR
    MOORE, KW
    [J]. SCIENCE, 1990, 250 (4982) : 830 - 832
  • [23] Epstein-Barr Virus (EBV)-associated Gastric Carcinoma
    Iizasa, Hisashi
    Nanbo, Asuka
    Nishikawa, Jun
    Jinushi, Masahisa
    Yoshiyama, Hironori
    [J]. VIRUSES-BASEL, 2012, 4 (12): : 3420 - 3439
  • [24] Human B cells on their route to latent infection - Early but transient expression of lytic genes of Epstein-Barr virus
    Kalla, Markus
    Hammerschmidt, Wolfgang
    [J]. EUROPEAN JOURNAL OF CELL BIOLOGY, 2012, 91 (01) : 65 - 69
  • [25] EBV genome carrying B lymphocytes that express the nuclear protein EBNA-2 but not LMP-1 Type IIb latency
    Klein, Eva
    Nagy, Noemi
    Rasul, Abu Eahsan
    [J]. ONCOIMMUNOLOGY, 2013, 2 (02):
  • [26] KLEIN G, 1987, ADV VIRAL ONCOL, P207
  • [27] Base-pair resolution DNA methylome of the EBV-positive Endemic Burkitt lymphoma cell line DAUDI determined by SOLiD bisulfite-sequencing
    Kreck, B.
    Richter, J.
    Ammerpohl, O.
    Barann, M.
    Esser, D.
    Petersen, B. S.
    Vater, I.
    Penas, E. M. Murga
    Chung, C. A. Bormann
    Seisenberger, S.
    Boyd, V. Lee
    Smallwood, S.
    Drexler, H. G.
    MacLeod, R. A. F.
    Hummel, M.
    Krueger, F.
    Haesler, R.
    Schreiber, S.
    Rosenstiel, P.
    Franke, A.
    Siebert, R.
    [J]. LEUKEMIA, 2013, 27 (08) : 1751 - 1753
  • [28] Epstein-Barr Virus Zta Upregulates Matrix Metalloproteinases 3 and 9 That Synergistically Promote Cell Invasion In Vitro
    Lan, Yu-Yan
    Yeh, Tzu-Hao
    Lin, Wei-Hung
    Wu, Shih-Yi
    Lai, Hsiao-Ching
    Chang, Fang-Hsin
    Takada, Kenzo
    Chang, Yao
    [J]. PLOS ONE, 2013, 8 (02):
  • [29] EPSTEIN-BARR-VIRUS (EBV)-CARRYING CELLS OF A CHRONIC LYMPHOCYTIC-LEUKEMIA (CLL) SUBPOPULATION EXPRESS EBNA1 AND LMPS BUT NOT EBNA2 IN-VIVO
    LAYTRAGOONLEWIN, N
    CHEN, F
    AVILACARINO, J
    ZOU, JZ
    MELLSTEDT, H
    ERNBERG, I
    KLEIN, G
    [J]. INTERNATIONAL JOURNAL OF CANCER, 1995, 63 (04) : 486 - 490
  • [30] LENOIR GM, 1987, ADV VIRAL ONCOL, V7, P173