Chemical kindling and seizure susceptibility in morphine dependent rats

被引：10

作者：

Atapour, N ^{[1
]}

Kalantaripour, TP ^{[1
]}

Nourpanah, M ^{[1
]}

Niazi, M ^{[1
]}

机构：

[1] Kerman Univ Med Sci, Neurosci Res Ctr, Kerman, Iran

来源：

EUROPEAN NEUROPSYCHOPHARMACOLOGY | 2000年 / 10卷 / 06期

关键词：

morphine-dependence; PTZ-kindling; NMDA; picrotoxin; caffeine;

D O I：

10.1016/S0924-977X(00)00123-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In the present study, we investigated whether and how chronic morphine administration changes seizure susceptibility in rats. The role of morphine-dependence on the seizure susceptibility has been evaluated with models of pentylenetetrazol (PTZ)-kindling and acute convulsions induced by PTZ, N-methyI-D-aspartic acid (NMDA), picrotoxin and caffeine in adult male rats. The results showed that morphine-dependence increased seizure severity only at 1-4th PTZ injections in the kindling model. In acute convulsion tests, dependent rats demonstrated a significantly lower seizure threshold only for PTZ, while they demonstrated a significantly lower tendency to show tonic-clonic convulsions only for NMDA. It is concluded that morphine-dependence may modulate PTZ-kindling and seizure susceptibility in rats with emphasis on the role of GABA and NMDA neurotransmitter systems. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：483 / 487

页数：5

共 24 条

[1] EFFECT OF DIFFERENT CONVULSANT DRUGS ON SOME SEIZURE PARAMETERS IN MORPHINE-DEPENDENT MICE [J].