Enantiospecific total synthesis of TAN1251C and TAN1251D

被引：20
|
作者：
Mizutani, H [1 ]
Takayama, J [1 ]
Honda, T [1 ]
机构：
[1] Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, Japan
来源：
SYNLETT | 2005年 / 02期
关键词：
TAN1251; alkaloid; total synthesis; aromatic oxidations; hypervalent iodine; spiro cyclization;
D O I：
10.1055/s-2004-836065
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An enantiospecific total synthesis of TAN1251C and TAN1251D has been achieved. An aromatic oxidation reaction of a secondary amine, which is prepared from two molecules of L-tyrosine derivatives, with hypervalent iodine reagent gave a spirocyclic product as a key intermediate for the synthesis of TAN 1251C and D.
引用
收藏
页码：328 / 330
页数：3
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