Improving Outcome After Major Surgery: Pathophysiological Considerations

被引:37
作者
Banz, Vanessa M. [2 ]
Jakob, Stephan M. [1 ,3 ]
Inderbitzin, Daniel [2 ]
机构
[1] Univ Hosp Bern, Inselspital, Dept Intens Care Med, CH-3010 Bern, Switzerland
[2] Univ Hosp Bern, Inselspital, Dept Visceral Surg & Med, CH-3010 Bern, Switzerland
[3] Univ Bern, CH-3010 Bern, Switzerland
关键词
THORACIC EPIDURAL-ANESTHESIA; ABDOMINAL AORTIC-ANEURYSM; GASTROINTESTINAL CANCER-PATIENTS; INTRAOPERATIVE FLUID MANAGEMENT; SHORT-TERM OUTCOMES; HIGH-RISK PATIENTS; POSTOPERATIVE COMPLICATIONS; PROINFLAMMATORY CYTOKINES; MORBID-OBESITY; HEART-FAILURE;
D O I
10.1213/ANE.0b013e3181ed114e
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Surgical and anesthesia-related techniques may reduce physical stress for patients undergoing high-risk surgery, but major surgery is increasingly performed in patients with substantial comorbidities. Strategies for improving the outcome for such patients include approaches that both increase tissue oxygen delivery and reduce metabolic demand. However, these strategies have produced conflicting results. To understand the success and failure of attempts to improve postoperative outcome, the pathophysiology of perioperative hemodynamic, metabolic, and immunological alterations should be analyzed. Our aim in this review is to provide a survey of fields of opportunities for improving outcome after major surgery. The issues are approached from 3 different angles: the view of the patient, the view of the surgical intervention, and the view of the anesthesia. Special attention is also given to what could be considered the result of the interaction among the 3: perioperative inflammation and immune response. (Anesth Analg 2011;112:1147-55)
引用
收藏
页码:1147 / 1155
页数:9
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