High-Grade Neuroendocrine Carcinoma of the Head and Neck: Human Papillomavirus Status and PD-L1 Expression

被引：5

作者：

Bahr, Katharina ^{[1
]}

Zimmer, Stefanie ^{[2
]}

Springer, Erik ^{[3
]}

Fottner, Christian ^{[4
]}

Becker, Sven ^{[1
]}

Ernst, Benjamin P. ^{[1
]}

Matthias, Christoph ^{[1
]}

Kuenzel, Julian ^{[1
,5
]}

机构：

[1] Univ Med Ctr Mainz, Dept Otorhinolaryngol Head & Neck Surg, Mainz, Germany

[2] Univ Med Ctr Mainz, Inst Pathol & Tissue Biobank, Mainz, Germany

[3] Univ Med Ctr Mainz, Inst Mol Pathol, Mainz, Germany

[4] Univ Med Ctr Mainz, Dept Endocrine & Neuroendocrine Tumors, Mainz, Germany

[5] Univ Hosp Regensburg, Dept Otorhinolaryngol Head & Neck Surg, Franz Josef Str Allee 11, DE-55131 Regensburg, Germany

来源：

ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY HEAD AND NECK SURGERY | 2019年 / 81卷 / 5-6期

关键词：

Neuroendocrine carcinoma; Human papillomavirus; PD-L1; Head and neck; Immunotherapy; CELL LUNG-CANCER; PREDICTIVE BIOMARKER; PROGNOSTIC-FACTORS; OPEN-LABEL; OROPHARYNX; IMMUNOTHERAPY; PEMBROLIZUMAB; MULTICENTER; NIVOLUMAB; DISTINCT;

D O I：

10.1159/000502325

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background: Human papillomavirus (HPV)-related head and neck squamous cell carcinoma represents an important subgroup of head and neck cancer, but HPV occurs also in the less common neuroendocrine carcinomas (NEC). The PD-1/PD-L1 pathway appears to be activated in pulmonary NEC and correlates with a higher mutation burden, but the potential of NEC to respond to checkpoint inhibitors is unknown to a large extent. Objectives: To determine the HPV status of NEC of the head and neck region and to investigate the expression of PD-1 and its ligands PD-L1 and PD-L2. Methods: Surgical tumor samples from 2006 to 2017 were analyzed. HPV status was determined by p16 immunohistochemistry (IHC) and multiplex PCR. IHC using the Cologne Score was performed for PD-1, PD-L1, and PD-L2. Results: Seven NEC tumor samples were analyzed, three of them showed HPV type 18. Expression of PD-1 and PD-L1 differed widely and showed no correlation to HPV status. IHC showed an overexpression of PD-L2 in most of the patients.

引用

页码：309 / 316

页数：8

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