Anti-SIRT1 autoantibody is elevated in ankylosing spondylitis: a potential disease biomarker

被引：14

作者：

Hu, Qiongyi ^{[1
]}

Sun, Yue ^{[1
]}

Li, Yuan ^{[2
,3
]}

Shi, Hui ^{[1
]}

Teng, Jialin ^{[1
]}

Liu, Honglei ^{[1
]}

Cheng, Xiaobing ^{[1
]}

Ye, Junna ^{[1
]}

Su, Yutong ^{[1
]}

Yin, Yufeng ^{[1
]}

Liu, Mengru ^{[1
]}

Wang, Jiucun ^{[2
,3
]}

Yang, Chengde ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Rheumatol & Immunol, 197 Ruijin Second Rd, Shanghai 200025, Peoples R China

[2] Fudan Univ, State Key Lab Genet Engn, Collaborat Innovat Ctr Genet & Dev, Sch Life Sci, Shanghai 200438, Peoples R China

[3] Fudan Univ, Key Lab Contemporary Anthropol, Collaborat Innovat Ctr Genet & Dev, Sch Life Sci,Minist Educ MOE, Shanghai 200438, Peoples R China

来源：

BMC IMMUNOLOGY | 2018年 / 19卷

基金：

中国国家自然科学基金;

关键词：

AS; Anti-SIRT1; antibodies; Biomarker; III HISTONE DEACETYLASE; CLASSIFICATION CRITERIA; PSORIATIC-ARTHRITIS; SIRTUIN; ANTIBODIES; PATHOGENESIS; SCLEROSTIN; AUTOIMMUNE; REGULATOR; REPRESSOR;

D O I：

10.1186/s12865-018-0280-x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

BackgroundLittle is known about the presence of specific autoantibodies in ankylosing spondylitis (AS), an immune-mediated inflammatory disease. The object of this study was to explore potential autoantibody profiles in AS patients.ResultsLevels of anti-SIRT1 autoantibodies were significantly higher in AS (P<0.001) and psoriatic arthritis (PsA) (P<0.01) patients but not rheumatoid arthritis (RA) patients compared with healthy controls. Additionally, titers of anti-NAD-dependent protein deacetylase sirtuin-1(SIRT1) antibodies were significantly higher in AS patients than in RA (P<0.05) and PsA (P<0.05) patients. Moreover, levels of anti-SIRT1 (P<0.001) antibodies were significantly higher during the first year in patients with hip joint involvement. The anti-SIRT1 antibody positivity rate was 18.9% in AS patients.ConclusionsOur findings indicate that anti-SIRT1 autoantibodies may serve as a marker for diagnosing AS and predicting hip joint involvement at an early stage.

引用

页数：8

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