Deafness-related decreases in glycine-immunoreactive labeling in the rat cochlear nucleus

被引：37
作者：
Asako, M
Holt, AG
Griffith, RD
Buras, ED
Altschuler, RA
机构：
[1] Univ Michigan, Kresge Hearing Res Inst, Dept Otolaryngol Head Neck Surg, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Dept Cell & Dev Biol, Ann Arbor, MI 48109 USA
[3] Kansai Med Univ, Dept Otolaryngol Head Neck Surg, Osaka, Japan
来源：
JOURNAL OF NEUROSCIENCE RESEARCH | 2005年 / 81卷 / 01期
关键词：
hearing; auditory; ablation; neurotransmitter;
D O I：
10.1002/jnr.20542
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
There is increasing evidence of activity-related plasticity in auditory pathways. The present study examined the effects of decreased activity on immunolocalization of the inhibitory neurotransmitter glycine in the cochlear nucleus of the rat after bilateral cochlear ablation. Specifically, glycine-immunoreactive puncta adjacent to somatic profiles were compared in normal hearing animals and animals deafened for 14 days. The number of glycine-immunoreactive puncta surrounding somatic profiles of spherical and globular bushy cells, glycine-immunoreactive type I stellate multipolar cells, radiate neurons (type II stellate multipolar cells), and fusiform cells decreased significantly. In addition, the number of glycine immunopositive tuberculoventral (vertical or corn) cells in the deep layer of the dorsal cochlear nucleus also decreased significantly. These results suggest that decreased inhibition reported in cochlear nucleus after deafness may be due to decreases in glycine. (c) 2005 Wiley-Liss, Inc.
引用
收藏
页码：102 / 109
页数：8
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